发明授权
US08114873B2 1,4-disubstituted naphthalenes as inhibitors of p38 map kinase
有权
1,4-二取代萘作为p38映射激酶的抑制剂
- 专利标题： 1,4-disubstituted naphthalenes as inhibitors of p38 map kinase
- 专利标题（中）： 1,4-二取代萘作为p38映射激酶的抑制剂
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申请号： US12854687申请日： 2010-08-11
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公开(公告)号： US08114873B2公开(公告)日： 2012-02-14
- 发明人: Mark A. Ashwell , Yanbin Liu , Syed M. Ali , Jason Hill , Woj Wrona
- 申请人： Mark A. Ashwell , Yanbin Liu , Syed M. Ali , Jason Hill , Woj Wrona
- 申请人地址： US MA Woburn
- 专利权人： ArQule, Inc.
- 当前专利权人： ArQule, Inc.
- 当前专利权人地址： US MA Woburn
- 代理机构： Sunstein Kann Murphy & Timbers LLP
- 主分类号： A61K31/5355
- IPC分类号： A61K31/5355 ; A61K31/5375 ; C07D265/30 ; A61P29/00
摘要：
Naphthalene-based compounds having linked heterocyclic and aromatic rings capable of inhibiting P38, methods for inhibiting P38 in vivo or in vitro, diagnostics for determining activity in the treatment of P38 and/or cytokine-associated conditions and methods for treating conditions associated with P38 activity or cytokine activity; more particularly naphthalene-based compounds of Formula (I) having a morpholine heterocyclic ring, and methods of use thereof