A tire control system for a vehicle is provided includes an RFID tag mounted to the tire and having a unique tire serial number stored within tag memory accessible to an external reader; a pass-through portal operatively entered and exited by the vehicle; one or more tire-directed antenna positioned within the portal for operatively receiving one or more one data transmissions of the unique tire serial number from the tire-based RFID tag; and one or more tire-directed RFID reader coupled to the tire-directed antennas for operably reading and storing within a tire-based database the unique tire serial number data. A vehicle-based RFID tag is mounted to the vehicle having a unique vehicle serial number stored within tag memory and transmitted to an external reader as the vehicle moves through the portal. A data processing computer is coupled to receive the portal-read unique tire serial number and vehicle serial number and conducts of the portal-read unique tire serial number data and the unique vehicle serial number data against prestored reference tire serial number data and prestored reference vehicle serial number data, respectively.