发明授权
- 专利标题： Nanoparticulate and controlled release compositions comprising cefditoren
- 专利标题（中）： 包含头孢托仑的纳米颗粒和控释组合物
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申请号： US11671276申请日： 2007-02-05
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公开(公告)号： US08119163B2公开(公告)日： 2012-02-21
- 发明人: John G Devane , Paul Stark , Niall M. N. Fanning , Gurvinder Singh Rekhi , Scott A. Jenkins , Gary Liversidge
- 申请人： John G Devane , Paul Stark , Niall M. N. Fanning , Gurvinder Singh Rekhi , Scott A. Jenkins , Gary Liversidge
- 申请人地址： IE Dublin
- 专利权人： Alkermes Pharma Ireland Limited
- 当前专利权人： Alkermes Pharma Ireland Limited
- 当前专利权人地址： IE Dublin
- 代理机构： Fox Rothschild LLP
- 主分类号： A61K9/14
- IPC分类号： A61K9/14 ; A61K9/16 ; A61K9/50 ; A61K9/54
摘要：
The present invention provides a composition comprising a cefditoren, or a salt, derivative, prodrug, or other form thereof, for example, cefditoren pivoxil, useful in the treatment and prevention of infections and related conditions. The invention provides a composition which comprises nanoparticulate particles comprising the cefditoren, or a salt, derivative, prodrug, or other form thereof and at least one surface stabilizer. The nanoparticulate particles have an effective average particle size of less than about 2000 nm. The invention provides also a composition that delivers a cefditoren, or a salt, derivative, prodrug, or other form thereof, or nanoparticles comprising the same, in a pulsatile or continuous manner.
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