发明授权
US08119770B2 Modified soluble FGF receptor Fc fusions with improved biological activity
失效
具有改善生物活性的改良的可溶性FGF受体Fc融合体
- 专利标题: Modified soluble FGF receptor Fc fusions with improved biological activity
- 专利标题(中): 具有改善生物活性的改良的可溶性FGF受体Fc融合体
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申请号: US12515463申请日: 2007-11-28
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公开(公告)号: US08119770B2公开(公告)日: 2012-02-21
- 发明人: Francis Blanche , Beatrice Cameron , Mark Nesbit , Sylvie Sordello , Celine Nicolazzi , Marc Trombe
- 申请人: Francis Blanche , Beatrice Cameron , Mark Nesbit , Sylvie Sordello , Celine Nicolazzi , Marc Trombe
- 申请人地址: FR Antony
- 专利权人: Aventis Pharma SA
- 当前专利权人: Aventis Pharma SA
- 当前专利权人地址: FR Antony
- 代理机构: Lathrop & Gage LLP
- 代理商 James H. Velema, Esq.
- 优先权: EP06291824 20061128; EP07290042 20070111
- 国际申请: PCT/IB2007/004354 WO 20071128
- 国际公布: WO2008/065543 WO 20080605
- 主分类号: C07K14/705
- IPC分类号: C07K14/705 ; C07K14/18
摘要:
The invention relates to modified soluble FGF receptor Fc fusions comprising a fusion of a soluble fragment or domain of the FGF receptor part (targeting or binding moiety) with an Fc region of an immunoglobulin part (effector function moiety), having improved biological activity including ADCC/CDC activities, compositions containing them, and method of producing such modified soluble FGF receptor Fc fusion molecules.
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