A method and apparatus for removing an echo signal in a signal transmission/reception apparatus of a communication system is provided. A signal transmission/reception apparatus estimates an input channel response using a training sequence, generates a first signal by removing the input channel response from a first reception signal, detects an echo channel impulse response using the first signal, detects an echo signal removing coefficient using the echo channel impulse response, generates a second signal in which an echo signal is removed by applying the echo signal removing coefficient to a second reception signal, and removes the second signal from a third signal, wherein the first signal is received prior to receiving the second signal and the second signal is received prior to receiving the third signal.