发明授权
US08124134B2 Isolation of a dual COX-2 and 5-lipoxygenase inhibitor from Acacia
有权
从相思树中分离双重COX-2和5-脂氧合酶抑制剂
- 专利标题： Isolation of a dual COX-2 and 5-lipoxygenase inhibitor from Acacia
- 专利标题（中）： 从相思树中分离双重COX-2和5-脂氧合酶抑制剂
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申请号： US11457388申请日： 2006-07-13
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公开(公告)号： US08124134B2公开(公告)日： 2012-02-28
- 发明人: Qi Jia , Timothy C. Nichols , Eric Rhoden , Scott Waite
- 申请人： Qi Jia , Timothy C. Nichols , Eric Rhoden , Scott Waite
- 申请人地址： US WA Lacey
- 专利权人： Unigen, Inc.
- 当前专利权人： Unigen, Inc.
- 当前专利权人地址： US WA Lacey
- 代理机构： Seed IP Law Group PLLC
- 主分类号： A01N65/00
- IPC分类号： A01N65/00
摘要：
The present invention provides a novel method for simultaneously inhibiting the cyclooxygenase COX-2 and 5-lipoxygenase (5-LO) enzymes. The method for the simultaneous dual inhibition of COX-2 and 5-LO is comprised of administering a composition containing an individual and/or a mixture of multiple flavans isolated from a single plant or multiple plants in the Acacia genus of plants to a host in need thereof. The present also includes novel methods for the prevention and treatment of COX-2 and 5-LO mediated diseases and conditions. The method for preventing and treating COX-2 and 5-LO mediated diseases and conditions is comprised of administering to a host in need thereof an effective amount of a composition comprising an individual and/or a mixture of multiple flavans isolated from a single plant or multiple plants in the Acacia genus of plants and a pharmaceutically acceptable carrier. The present invention includes a method for isolating and purifying a composition of flavans having dual specificity for COX-2 and 5-LO from the Acacia genus of plants.