Invention Grant
- Patent Title: Human monoclonal antibodies to CD70
- Patent Title (中): CD70的人单克隆抗体
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Application No.: US12065436Application Date: 2006-09-26
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Publication No.: US08124738B2Publication Date: 2012-02-28
- Inventor: Jonathan Alexander Terret , Li-sheng Lu , David John King , Josephine M. Cardarelli , Chin Pan , Haichun Huang , Marco A. Coccia
- Applicant: Jonathan Alexander Terret , Li-sheng Lu , David John King , Josephine M. Cardarelli , Chin Pan , Haichun Huang , Marco A. Coccia
- Applicant Address: US NJ Princeton
- Assignee: Medarex, Inc.
- Current Assignee: Medarex, Inc.
- Current Assignee Address: US NJ Princeton
- Agency: Baker Botts L.L.P.
- International Application: PCT/US2006/037753 WO 20060926
- International Announcement: WO2007/038637 WO 20070405
- Main IPC: C07K16/00
- IPC: C07K16/00 ; A61K39/395 ; A61K39/00

Abstract:
The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to CD70 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the disclosure are also provided. The disclosure also provides methods for treating cancer, autoimmune disease, inflammation and viral infections.
Public/Granted literature
- US20090028872A1 HUMAN MONOCLONAL ANTIBODIES TO CD70 Public/Granted day:2009-01-29
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