An access speculation predictor may predict whether to perform speculative retrieval of data for a data request from a main memory based on whether or not a domain indicator in the data request indicates that the cache line corresponding to the data has a special invalid state or not. In particular, a first address and a domain indicator are extracted from first data request. The first address is used to select a finite state machine (FSM) of a memory controller based on memory regions associated with the FSMs of the memory controller. Speculative retrieval of data for the first data request from main memory is controlled based on whether the domain indicator identifies the special invalid state or not and, if the domain indicator identifies that the cache line does not have the special invalid state, based on information stored in registers associated with the selected FSM.