发明授权
US08128803B2 Method and system for determining the concentration of an analyte/enzyme complex or of an analyte/enzyme conjugate, especially for the electrochemical detection of the analyte, and corresponding measuring device
有权
用于确定分析物/酶复合物或分析物/酶缀合物的浓度的方法和系统，特别是用于分析物的电化学检测，以及对应的测量装置
- 专利标题： Method and system for determining the concentration of an analyte/enzyme complex or of an analyte/enzyme conjugate, especially for the electrochemical detection of the analyte, and corresponding measuring device
- 专利标题（中）： 用于确定分析物/酶复合物或分析物/酶缀合物的浓度的方法和系统，特别是用于分析物的电化学检测，以及对应的测量装置
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申请号： US11989938申请日： 2006-07-31
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公开(公告)号： US08128803B2公开(公告)日： 2012-03-06
- 发明人: Heike Barlag , Walter Gumbrecht , Konrad Mund
- 申请人： Heike Barlag , Walter Gumbrecht , Konrad Mund
- 申请人地址： DE Munich
- 专利权人： Siemens Aktiengesellschaft
- 当前专利权人： Siemens Aktiengesellschaft
- 当前专利权人地址： DE Munich
- 代理机构： Staas & Halsey LLP
- 优先权： DE102005037436 20050804
- 国际申请： PCT/EP2006/064842 WO 20060731
- 国际公布： WO2007/014931 WO 20070208
- 主分类号： G01N33/543
- IPC分类号： G01N33/543 ; G01N27/26 ; G01N27/49
摘要：
A method follow the change in concentration of a redox-active substance, whereby suitable potentials for a reduction process or an oxidation process are applied to the working electrode of a measuring device. The potential of the working electrode is pulsed and measuring phases and relaxation phases are alternately produced, the pulse lengths of measuring phase and relaxation phase being determined in a suitable manner. A rapid relaxation of the concentration gradient is electrochemically forced so that the measurement can be carried out on simple transducer arrays. A device for carrying out the method includes a transducer array in addition to a suitable potentiostat. The transducer array can be formed of a planar metal substrate on which at least one flexible insulator is disposed, the metal surface and the insulator surface being firmly linked. The transducer array can also be formed of silicone-based CMOS structures.
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