发明授权
- 专利标题： Method of predicting metastasis of oral cavity cancer into cervical lymph node and diagnosis kit to be used in the prediction
- 专利标题（中）： 预测口腔癌转移到宫颈淋巴结的方法和预测中使用的诊断试剂盒
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申请号： US12310331申请日： 2007-03-30
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公开(公告)号： US08129122B2公开(公告)日： 2012-03-06
- 发明人: Takashi Imai , Mayumi Iwakawa , Hitoshi Shibuya , Masahiko Miura , Ryoichi Yoshimura , Hiroshi Watanabe
- 申请人： Takashi Imai , Mayumi Iwakawa , Hitoshi Shibuya , Masahiko Miura , Ryoichi Yoshimura , Hiroshi Watanabe
- 申请人地址： JP Chiba-Shi, Chiba
- 专利权人： National Institute of Radiological Sciences
- 当前专利权人： National Institute of Radiological Sciences
- 当前专利权人地址： JP Chiba-Shi, Chiba
- 代理机构： Squire Sanders (US) LLP
- 优先权： JP2006-237793 20060901
- 国际申请： PCT/JP2007/057151 WO 20070330
- 国际公布： WO2008/026340 WO 20080306
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C07H21/04 ; C12N15/11 ; C12N15/12
摘要：
A method for objectively predicting possibility of metastasis to a cervical lymph node in an early stage for an individual case diagnosed as an oral cavity cancer, and a diagnosis kit to be used in the prediction are provided. The method includes a step of assaying expression amounts of metastasis prediction genes in which the expression amounts are changed between a metastasis group and a non-metastasis group, with respect to a sample collected from a primary legion of the oral cavity cancer. Further, the method includes a step of predicting the possibility of the metastasis by comparing the expression amounts of the metastasis gene group with the expression amounts of the metastasis prediction genes in a metastasis group and/or a non-metastasis group. Herein, the metastasis prediction gene group includes two genes MSR1 (NM_138716.1) and RET (M31213.1).
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