发明授权
- 专利标题： Sperm-specific cation channel, CatSper4, and uses therefor
- 专利标题（中）： 精子特异性阳离子通道，CatSper4，并用于此
-
申请号： US12244630申请日： 2008-10-02
-
公开(公告)号： US08137918B2公开(公告)日： 2012-03-20
- 发明人: Magdalene M. Moran , Jayhong A. Chong , Ian S. Ramsey , David Clapham
- 申请人： Magdalene M. Moran , Jayhong A. Chong , Ian S. Ramsey , David Clapham
- 申请人地址： US MA Boston
- 专利权人： Children's Medical Center Corporation
- 当前专利权人： Children's Medical Center Corporation
- 当前专利权人地址： US MA Boston
- 代理机构： Wilmer Cutler Pickering Hale and Dorr LLP
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; A01N61/00 ; A61K31/00 ; C40B30/00
摘要：
Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper4) are disclosed. The CatSper4 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper4 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper4 activity, methods of genotyping subjects with respect to CatSper4, and methods of diagnosing and treating CatSper4-mediated disorders, including infertility. Related business methods are also disclosed.
公开/授权文献
信息查询
