发明授权
- 专利标题: Benzimidazolone derivatives as CB2 receptor ligands
- 专利标题(中): 苯并咪唑酮衍生物作为CB2受体配体
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申请号: US11909763申请日: 2006-03-02
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公开(公告)号: US08138177B2公开(公告)日: 2012-03-20
- 发明人: Kazuo Ando , Makoto Kawai , Tsutomu Masuda , Hirofumi Omura
- 申请人: Kazuo Ando , Makoto Kawai , Tsutomu Masuda , Hirofumi Omura
- 申请人地址: US NY New York
- 专利权人: Pfizer Inc.
- 当前专利权人: Pfizer Inc.
- 当前专利权人地址: US NY New York
- 代理商 James T. Wasicak; Lucy X. Yang
- 国际申请: PCT/IB2006/000521 WO 20060302
- 国际公布: WO2006/097808 WO 20060921
- 主分类号: A61K31/541
- IPC分类号: A61K31/541 ; A61K31/5377 ; A61K31/454 ; C07D413/02 ; C07D211/32 ; C07D471/02
摘要:
This invention relates to compounds of the formula (I): or pharmaceutically acceptable salts thereof, wherein: A, B, R1, R2 and R3 are each as described herein, and compositions containing such compounds and the use of such compounds in the treatment of a condition mediated by CB2 receptor binding activity such as, but not limited to, inflammatory pain, nociceptive pain, neuropathic pain, fibromyalgia, chronic low back pain, visceral pain, acute cerebral ischemia, pain, chronic pain, acute pain, post herpetic neuralgia, neuropathies, neuralgia, diabetic neuropathy, HIV-related neuropathy, nerve injury, rheumatoid arthritic pain, osteoarthritic pain, back pain, cancer pain, dental pain, fibromyalgia, neuritis, sciatica, inflammation, neurodegenerative disease, cough, broncho constriction, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), colitis, cerebrovascular ischemia, emesis such as cancer chemotherapy-induced emesis, rheumatoid arthritis, asthma, Crohn's disease, ulcerative colitis, asthma, dermatitis, seasonal allergic rhinitis, gastroesophageal reflux disease (GERD), constipation, diarrhea, functional gastrointestinal disorder, cutaneous T cell lymphoma, multiple sclerosis, osteoarthritis, psoriasis, systemic lupus erythematosus, diabetes, glaucoma, osteoporosis, glomerulonephritis, renal ischemia, nephritis, hepatitis, cerebral stroke, vasculitis, myocardial infarction, cerebral ischemia, reversible airway obstruction, adult respiratory disease syndrome, chronic obstructive pulmonary disease (COPD), cryptogenic fibrosing alveolitis or bronchitis.
公开/授权文献
- US20090181957A1 BENZIMIDAZOLONE DERIVATIVES AS CB2 RECEPTOR LIGANDS 公开/授权日:2009-07-16
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