发明授权
US08143031B2 Production of N-acylated sulphur-containing amino acids with microorganisms having enhanced N-acyltransferase enzymatic activity
失效
用具有增强的N-酰基转移酶酶活性的微生物生产N-酰化的含硫氨基酸
- 专利标题： Production of N-acylated sulphur-containing amino acids with microorganisms having enhanced N-acyltransferase enzymatic activity
- 专利标题（中）： 用具有增强的N-酰基转移酶酶活性的微生物生产N-酰化的含硫氨基酸
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申请号： US12370434申请日： 2009-02-12
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公开(公告)号： US08143031B2公开(公告)日： 2012-03-27
- 发明人: Rainer Figge , Guillaume Barbier , Gwénaëlle Bestel-Corre
- 申请人： Rainer Figge , Guillaume Barbier , Gwénaëlle Bestel-Corre
- 申请人地址： FR Saint Beauzire
- 专利权人： Metabolic Explorer
- 当前专利权人： Metabolic Explorer
- 当前专利权人地址： FR Saint Beauzire
- 代理机构： Bozicevic, Field & Francis, LLP
- 代理商 Shweta Chandra; Carol L. Francis
- 主分类号： C12N1/15
- IPC分类号： C12N1/15 ; C12N1/19
摘要：
The present invention claims an isolated polypeptide having L-amino-acid-N-acyl transferase enzymatic activity and a modified microorganism in which this enzyme is overexpressed. Substrates of said enzyme include mainly methionine and their derivatives or analogs. Overexpression in sulphur-containing amino acid producing microorganisms permits the production of large amounts of N-acylated sulphur-containing amino acids. The isolation of the N-acylated sulphur-containing amino acids from the fermentation medium is also claimed.
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