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    Display module set and display screen
    1.
    发明授权
    Display module set and display screen 有权

    公开(公告)号：US12231805B2

    公开(公告)日：2025-02-18

    申请号：US18025725

    申请日：2022-11-29

    Applicant: NANJING LOPU CO., LTD. ,  NANJING LOPU TECHNOLOGY CO., LTD.

    Inventor： Bin Zhu ,  Deyu Han ,  Sheng Li ,  Ning Xu ,  Xiuwei Lv ,  Chengbing Guo ,  Lingling Jiang ,  Yezhuang Xu

    IPC: H04N5/64 ,  G09G3/32

    Abstract: The present disclosure relates to the technical field of display screen, and provides a display module set and a display screen. The display module set comprises a cabinet frame and a plurality of display modules. The cabinet frame comprises a power box and a plurality of sub-frames located on the left and right sides of the power box. The sub-frames on each side are arranged sequentially in a vertical direction. The plurality of the display modules corresponds to a plurality of the sub-frames on a one-to-one basis. A drive circuit and mounting members of the display module are both provided on a left side and/or right side region. A middle region of the display module is uniformly distributed with a hole structure for sound transmission. The display module is mounted on a corresponding sub-frame via the mounting members of the left side and/or right side region.

    CasY compositions and methods of use
    2.
    发明授权
    CasY compositions and methods of use 有权

    公开(公告)号：US12227753B2

    公开(公告)日：2025-02-18

    申请号：US16755534

    申请日：2018-10-31

    Applicant: The Regents of the University of California

    Inventor： Jennifer A. Doudna ,  David Burstein ,  Janice S. Chen ,  Lucas B. Harrington ,  David Paez-Espino ,  Jillian F. Banfield

    IPC: C12N15/82 ,  C12N9/22 ,  C12N15/113 ,  C12N15/85

    Abstract: Provided are compositions and methods that include a CasY transactivating noncoding RNA (trancRNA) (referred to herein as a “CasY trancRNA”), nucleic acids encoding the CasY trancRNA, and/or a modified host cell comprising the CasY trancRNA (and/or a nucleic acid encoding the same). Subject compositions and methods can also include one or more of: (a) a “CasY” protein (also referred to as a CasY polypeptide, a Cas12d protein, and a Cas12d polypeptide), a nucleic acid encoding the CasY protein, and/or a modified host cell comprising the CasY protein (and/or a nucleic acid encoding the same); and (b) a CasY guide RNA (also referred to herein as a “Cas12d guide RNA”) that binds to and provides sequence specificity to the CasY protein, a nucleic acid encoding the CasY guide RNA, and/or a modified host cell comprising the CasY guide RNA (and/or a nucleic acid encoding the same).

    Multi-laser systems having modified beam profiles and methods of use thereof
    4.
    发明授权
    Multi-laser systems having modified beam profiles and methods of use thereof 有权

    公开(公告)号：US12222518B2

    公开(公告)日：2025-02-11

    申请号：US16381891

    申请日：2019-04-11

    Applicant: BECTON, DICKINSON AND COMPANY

    Inventor： Eric D. Diebold ,  Jizuo Zou ,  Jorge Manzarraga

    IPC: G02B27/10 ,  G01N15/1434 ,  G02B3/00 ,  G02B19/00 ,  G02B27/09

    Abstract: Aspects of the present disclosure include systems with multiple lasers having modified beam profiles. Systems according to certain embodiments include a first laser that produces a first beam of light, a second laser that produces a second beam of light and a beam shaping component that receives the first beam of light and the second beam of light at substantially the same position from different angles of incidence and is configured to generate from the first beam of light and the second beam of light an output beam of light having a predetermined intensity profile along a horizontal axis. Methods for irradiating a sample in a flow stream with the output beam of light are also described. Kits having one or more lasers and a beam shaping component configured to generate from a first beam of light and a second beam of light an output beam of light having a predetermined intensity profile along a horizontal axis are also provided.

    Battery assembly locking device and automated guided vehicle
    5.
    发明授权
    Battery assembly locking device and automated guided vehicle 有权

    公开(公告)号：US12206123B2

    公开(公告)日：2025-01-21

    申请号：US17283345

    申请日：2019-09-30

    Applicant: Hangzhou Hikrobot Co., Ltd.

    Inventor： Hui Jiang ,  Chao Wu ,  Juming Huang ,  Wentao Yu

    IPC: H01M50/264 ,  H01M50/204 ,  H01M50/289

    Abstract: A battery assembly locking device and an automated guided vehicle comprising the battery assembly locking device. The battery assembly locking device comprises: a battery assembly (1); locking hooks (12), which are installed on the battery assembly (1); a locking member (22), which is installed on a vehicle body (3) of an automated guided vehicle; and unlocking members (13), which are installed on the battery assembly (1), wherein the battery assembly (1) is locked on the locking member (22) by means of the locking hooks (12), and is locked on the vehicle body (3) of the automated guided vehicle; and the locking hooks (12) push the locking member (22) by means of the unlocking members (13), and are unlocked from the locking member (22). By using the cooperation of the locking hooks (12) and the locking member (22) and the cooperation of the unlocking members (13) and the locking member (22), the battery assembly (1) may be locked on the vehicle body (3) of the automated guided vehicle, or the locking hooks (12) may be unlocked from the locking member (22) so that the battery assembly (1) and the vehicle body (3) of the automated guided vehicle are unlocked, thus facilitating the unlocking and disassembly of batteries, which is suitable for automated battery replacement of large batches of batteries.

    Methods of treating myelodysplastic syndrome
    6.
    发明授权
    Methods of treating myelodysplastic syndrome 有权

    公开(公告)号：US12201645B2

    公开(公告)日：2025-01-21

    申请号：US16696103

    申请日：2019-11-26

    Applicant: Geron Corporation

    Inventor： Jacqueline Cirillo Bussolari ,  Fei Huang ,  Aleksandra Rizo

    IPC: A61K31/7125 ,  A61K31/4439 ,  A61K31/706 ,  A61P35/00 ,  G01N33/573

    Abstract: Methods of monitoring therapeutic efficacy in a subject with MDS are provided. Also provided is a method of identifying a subject with myelodysplastic syndrome (MDS) for treatment with a telomerase inhibitor, and methods of treating MDS. The subject methods can include administering to the subject an effective amount of a telomerase inhibitor and assessing the hTERT expression levels in a biological sample obtained from the subject. In some cases, a 50% or greater reduction in hTERT expression level identifies a subject who has an increased likelihood of benefiting from treatment with the telomerase inhibitor. The subject can be naive to treatment with a HMA, lenalidomide, or both. In some cases, the subject is classified as having low or intermediate-1 IPSS risk MDS and/or MDS relapsed/refractory to Erythropoiesis-Stimulating Agent (ESA). In some instances, the telomerase inhibitor is imetelstat sodium.

    Methods of analyzing capped ribonucleic acids
    8.
    发明授权
    Methods of analyzing capped ribonucleic acids 有权

    公开(公告)号：US12195794B2

    公开(公告)日：2025-01-14

    申请号：US17056378

    申请日：2019-05-22

    Applicant: The Regents of the University of California

    Inventor： Logan Mulroney ,  Mark Akeson ,  Miten Jain ,  Hugh Olsen

    IPC: C12Q1/6869 ,  C12P19/34

    Abstract: Provided are methods of analyzing capped ribonucleic acids (RNAs). The methods include translocating an adapted RNA through a nanopore of a nanopore device. The adapted RNA includes an RNA region, a 5′ cap, and an adapter polynucleotide attached to the 5′ cap. The methods include monitoring ionic current through the nanopore during the translocating, translocating the 5′ cap through the nanopore, and identifying one or more ionic current features characteristic of the 5′ cap (e.g., a triphosphate linkage between the 5′ cap and nucleotide N1 of the RNA region, a 5′ to 5′ orientation of the 5′ cap and nucleotide N1 of the RNA region, and/or the like), translocating through the nanopore. Also provided are computer-readable media, computer devices, and systems that find use, e.g., in practicing the methods of the present disclosure.

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