发明授权
- 专利标题: Malonamide derivatives with antithrombotic activity
- 专利标题(中): 具有抗血栓活性的丙二酰胺衍生物
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申请号: US12683736申请日: 2010-01-07
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公开(公告)号: US08143242B2公开(公告)日: 2012-03-27
- 发明人: Henning Steinhagen , Hauke Szillat , Markus Follmann , Reinhard Kirsch , Volkmar Wehner , Hans Matter , Martin Lorenz , Kent W. Neuenschwander , Anthony C. Scotese
- 申请人: Henning Steinhagen , Hauke Szillat , Markus Follmann , Reinhard Kirsch , Volkmar Wehner , Hans Matter , Martin Lorenz , Kent W. Neuenschwander , Anthony C. Scotese
- 申请人地址: FR Paris
- 专利权人: Sanofi-Aventis
- 当前专利权人: Sanofi-Aventis
- 当前专利权人地址: FR Paris
- 代理机构: Scully, Scott, Murphy & Presser, P.C.
- 优先权: EP07290877 20070710
- 主分类号: A61K31/553
- IPC分类号: A61K31/553 ; A61K31/4965 ; A61K31/44 ; A61K31/426 ; A61K31/381 ; A61K31/167 ; C07D281/06 ; C07D241/04 ; C07D213/65 ; C07D277/24 ; C07D409/02 ; C07C237/20
摘要:
The present invention relates to compounds of formula I, The compounds of formula I are valuable pharmacologically active compounds. They exhibit a strong anti-thrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardio-vascular disorders like thromboembolic diseases or restenoses. They are inhibitors of the blood clotting enzymes, especially factor VIIa and can in general be applied in conditions in which an undesired activity of factor VIIa is present or for the cure or prevention of which an inhibition of factor VIIa is intended. The invention furthermore relates to processes for the preparation of compounds of formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
公开/授权文献
- US20100249101A1 MALONAMIDE DERIVATIVES WITH ANTITHROMBOTIC ACTIVITY 公开/授权日:2010-09-30
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