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1.发明授权Ring-fused pyrimidines and triazines and use thereof for the treatment and/or prophylaxis of cardiovascular diseases 有权环稠合嘧啶和三嗪及其用于治疗和/或预防心血管疾病的用途公开(公告)号：US09216978B2
公开(公告)日：2015-12-22
申请号：US13806425
申请日：2011-07-05
申请人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Jens Ackerstaff , Nils Griebenow , Andreas Knorr , Frank Wunder , Volkhart Min-Jian Li , Walter Kroh , Lars Bärfacker
发明人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Jens Ackerstaff , Nils Griebenow , Andreas Knorr , Frank Wunder , Volkhart Min-Jian Li , Walter Kroh , Lars Bärfacker
IPC分类号： C07D471/04 , A61K31/53 , A61P9/12 , A61K45/06 , C07D487/04 , A61K31/519 , A61K31/527 , C07D491/107
CPC分类号： C07D471/04 , A61K31/519 , A61K31/527 , A61K31/53 , A61K45/06 , C07D487/04 , C07D491/107
摘要： The present application relates to novel fused pyrimidines and triazines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新的稠合嘧啶和三嗪，其制备方法，单独使用或组合用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途， 特别是用于治疗和/或预防心血管疾病。
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公开(公告)号：US09096592B2
公开(公告)日：2015-08-04
申请号：US13819337
申请日：2011-08-31
申请人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Jens Ackerstaff , Nils Griebenow , Andreas Knorr , Frank Wunder , Volkhart Min-Jian Li , Lars Bärfacker , Stefan Weigand
发明人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Jens Ackerstaff , Nils Griebenow , Andreas Knorr , Frank Wunder , Volkhart Min-Jian Li , Lars Bärfacker , Stefan Weigand
IPC分类号： A01N43/00 , A61K31/00 , C07D471/04 , C07D487/04 , C07D519/00 , A61K31/517 , A61K31/519 , A61K31/522 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D473/28 , C07D475/06 , C07D495/04 , C07D498/04 , C07D513/04
CPC分类号： C07D471/04 , A61K31/517 , A61K31/519 , A61K31/522 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D473/28 , C07D475/06 , C07D487/04 , C07D495/04 , C07D498/04 , C07D513/04 , C07D519/00
摘要： The present application relates to novel bicyclic azaheterocycles, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新型双环氮杂环，其制备方法，单独或组合用于治疗和/或预防疾病及其用于生产用于治疗和/或预防疾病的药物的用途 ，特别是用于治疗和/或预防心血管疾病。
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公开(公告)号：US09090610B2
公开(公告)日：2015-07-28
申请号：US14113214
申请日：2012-04-20
申请人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Nils Griebenow , Frank Wunder , Volkhart Min-Jian Li , Dieter Lang
发明人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Nils Griebenow , Frank Wunder , Volkhart Min-Jian Li , Dieter Lang
IPC分类号： C07D471/04 , A61K45/06 , C07D519/00 , A61K31/519 , A61K31/53
CPC分类号： C07D471/04 , A61K31/519 , A61K31/53 , A61K45/06 , C07D519/00
摘要： The present application relates to novel fluoroalkyl-substituted pyrazolopyridines, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prophylaxis of diseases and to their use for production of medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新的氟代烷基取代的吡唑并吡啶，其制备方法，其单独使用或组合用于治疗和/或预防疾病及其用于生产用于治疗和/或预防的药物的用途 的疾病，特别是用于治疗和/或预防心血管疾病。
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4.发明授权Ring-fused 4-aminopyrimidines and use thereof as stimulators of soluable guanylate cyclases 失效环稠合的4-氨基嘧啶及其可用作可溶性鸟苷酸环化酶的刺激剂公开(公告)号：US08765769B2
公开(公告)日：2014-07-01
申请号：US13704980
申请日：2011-07-05
申请人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Jens Ackerstaff , Nils Griebenow , Andreas Knorr , Frank Wunder , Volkhart Min-Jian Li
发明人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Jens Ackerstaff , Nils Griebenow , Andreas Knorr , Frank Wunder , Volkhart Min-Jian Li
IPC分类号： A01N43/54 , A01N43/90 , A61K31/517 , A61K31/519
CPC分类号： A61K31/519 , A61K45/06 , C07D471/04 , C07D491/20 , C07D519/00
摘要： The present application relates to novel fused 4-aminopyrimidines, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases and to the use thereof for production of medicaments for the treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新型融合的4-氨基嘧啶，其制备方法，单独或组合用于治疗和/或预防疾病的用途及其用于生产用于治疗和/或治疗的药物的用途 预防疾病，特别是用于治疗和/或预防心血管疾病。
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公开(公告)号：US20140100229A1
公开(公告)日：2014-04-10
申请号：US14113214
申请日：2012-04-20
申请人： Markus Follmann , Johannes-Peter Itasch , Gorden Redlich , Nils Griebenow , Frank Wunder , Volkhart Min-Jian Li , Dieter Lang
发明人： Markus Follmann , Johannes-Peter Itasch , Gorden Redlich , Nils Griebenow , Frank Wunder , Volkhart Min-Jian Li , Dieter Lang
IPC分类号： C07D471/04 , A61K45/06 , A61K31/519 , A61K31/53
CPC分类号： C07D471/04 , A61K31/519 , A61K31/53 , A61K45/06 , C07D519/00
摘要： The present application relates to novel fluoroalkyl-substituted pyrazolopyridines, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prophylaxis of diseases and to their use for production of medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新的氟代烷基取代的吡唑并吡啶，其制备方法，其单独使用或组合用于治疗和/或预防疾病及其用于生产用于治疗和/或预防的药物的用途 的疾病，特别是用于治疗和/或预防心血管疾病。
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![SUBSTITUTED 6-FLUORO-1H-PYRAZOLO[4,3-B]PYRIDINES AND USE THEREOF](/abs-image/US/2013/10/10/US20130267548A1/abs.jpg.150x150.jpg)
6.发明申请公开(公告)号：US20130267548A1
公开(公告)日：2013-10-10
申请号：US13882118
申请日：2011-11-03
申请人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Jens Ackerstaff , Nils Griebenow , Andreas Knorr , Frank Wunder , Volkhart Min-Jian Li , Joachim Mittendorf , Karl-Heinz Schlemmer , Rolf Jautelat
发明人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Jens Ackerstaff , Nils Griebenow , Andreas Knorr , Frank Wunder , Volkhart Min-Jian Li , Joachim Mittendorf , Karl-Heinz Schlemmer , Rolf Jautelat
IPC分类号： C07D471/04 , A61K45/06 , A61K31/506
CPC分类号： C07D471/04 , A61K31/506 , A61K45/06
摘要： The present application relates to novel substituted 6-fluoro-1H-pyrazolo[4,3-b]pyridines, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases and to the use thereof for preparing Medicaments for the treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新的取代的6-氟-1H-吡唑并[4,3-b]吡啶，其制备方法，其用途，单独或组合用于治疗和/或预防疾病，以及 其用于制备药物用于治疗和/或预防疾病，特别是用于治疗和/或预防心血管疾病。
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公开(公告)号：US08389764B2
公开(公告)日：2013-03-05
申请号：US12480348
申请日：2009-06-08
申请人： Christopher Kallus , Mark Broenstrup , Werngard Czechtizky , Andreas Evers , Markus Follmann , Nis Halland , Herman Schreuder
发明人： Christopher Kallus , Mark Broenstrup , Werngard Czechtizky , Andreas Evers , Markus Follmann , Nis Halland , Herman Schreuder
IPC分类号： C07C275/00 , C07C273/00 , C07C331/00 , C07C381/00
CPC分类号： A61K31/4164 , A61K31/17 , A61K31/18 , A61K31/198 , A61K31/223 , A61K31/36 , A61K31/381 , A61K31/40 , A61K31/4184 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4453 , A61K31/4465 , A61K45/06 , C07C307/06 , C07D207/06 , C07D209/20 , C07D211/34 , C07D211/58 , C07D213/40 , C07D213/55 , C07D213/73 , C07D235/14 , C07D261/08 , C07D295/185 , C07D317/58 , C07D333/20 , C07D487/08 , A61K2300/00
摘要： The invention relates to compounds of the formula I as defined herein, which are inhibitors of activated thrombin-activatable fibrinolysis inhibitor. The compounds of the formula I are suitable for manufacturing medicaments for the prophylaxis, secondary prevention and therapy of one or more disorders which are associated with thromboses, embolisms, hypercoagulability or fibrotic changes.
摘要翻译： 本发明涉及本文定义的式I化合物，其为活化凝血酶可激活的纤维蛋白溶解抑制剂的抑制剂。 式I的化合物适用于制备用于预防，二次预防和治疗与血栓形成，栓塞，高凝状态或纤维变性相关的一种或多种病症的药物。
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8.发明申请SUBSTITUTED 4-(INDAZOLYL)-1,4-DIHYDROPYRIDINES AND METHODS OF USE THEREOF 有权取代的4-（吲哚基）-1,4-二氢吡啶并及其使用方法公开(公告)号：US20110207731A1
公开(公告)日：2011-08-25
申请号：US12996465
申请日：2009-05-29
申请人： Martin Michels , Markus Follmann , Alexandros Vakalopoulos , Katja Zimmermann , Nicole Teusch , Karen Engel
发明人： Martin Michels , Markus Follmann , Alexandros Vakalopoulos , Katja Zimmermann , Nicole Teusch , Karen Engel
IPC分类号： A61K31/5377 , C07D401/10 , A61K31/4439 , C07D401/14 , C07D413/14 , A61K31/4545 , A61P35/00
CPC分类号： C07D401/04
摘要： This invention relates to novel 4-(indazolyl)-1,4-dihydropyridine og the following formula (I) derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions, particularly cancer and other proliferative disorders.
摘要翻译： 本发明涉及具有蛋白酪氨酸激酶抑制活性的下式（I）衍生物的新的4-（吲唑基）-1,4-二氢吡啶，其制备方法及其用于治疗c-Met 介导的疾病或c-Met介导的病症，特别是癌症和其他增殖性疾病。
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公开(公告)号：US20100035930A1
公开(公告)日：2010-02-11
申请号：US12480348
申请日：2009-06-08
申请人： Christopher KALLUS , Mark BROENSTRUP , Werngard CZECHTIZKY , Andreas EVERS , Markus FOLLMANN , Nis HALLAND , Herman SCHREUDER
发明人： Christopher KALLUS , Mark BROENSTRUP , Werngard CZECHTIZKY , Andreas EVERS , Markus FOLLMANN , Nis HALLAND , Herman SCHREUDER
IPC分类号： A61K31/195 , A61K31/27 , A61K31/42 , A61K31/40 , A61K31/381 , A61K31/4402 , A61K31/44 , A61K31/445 , A61P7/00 , C07C271/22 , C07C229/12 , C07D261/08 , C07D207/09 , C07D333/22 , C07D213/56 , C07D211/56
CPC分类号： A61K31/4164 , A61K31/17 , A61K31/18 , A61K31/198 , A61K31/223 , A61K31/36 , A61K31/381 , A61K31/40 , A61K31/4184 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4453 , A61K31/4465 , A61K45/06 , C07C307/06 , C07D207/06 , C07D209/20 , C07D211/34 , C07D211/58 , C07D213/40 , C07D213/55 , C07D213/73 , C07D235/14 , C07D261/08 , C07D295/185 , C07D317/58 , C07D333/20 , C07D487/08 , A61K2300/00
摘要： The invention relates to compounds of the formula I as defined herein, which are inhibitors of activated thrombin-activatable fibrinolysis inhibitor. The compounds of the formula I are suitable for manufacturing medicaments for the prophylaxis, secondary prevention and therapy of one or more disorders which are associated with thromboses, embolisms, hypercoagulability or fibrotic changes.
摘要翻译： 本发明涉及本文定义的式I化合物，其为活化凝血酶可激活的纤维蛋白溶解抑制剂的抑制剂。 式I的化合物适用于制备用于预防，二次预防和治疗与血栓形成，栓塞，高凝状态或纤维变性相关的一种或多种病症的药物。
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10.发明申请公开(公告)号：US20090233961A1
公开(公告)日：2009-09-17
申请号：US12400187
申请日：2009-03-09
IPC分类号： A61K31/472 , C07D217/22 , A61K31/4184 , C07D235/30 , A61P7/02
CPC分类号： C07D217/22 , C07C235/16 , C07C257/18 , C07D235/30
摘要： The invention relates to the compounds of formula I having antithrombotic activity which especially inhibits blood clotting factor IXa, to methods for producing the same and to the use thereof as drugs.
摘要翻译： 本发明涉及具有抗血栓形成活性的式I化合物，其特别是抑制血液凝固因子IXa，其制备方法及其作为药物的用途。
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