发明授权
US08143304B2 (3-amino-1,2,3,4-tetrahydro-9 H-carbazol-9-yl)-acetic acid derivatives
有权
(3-氨基-1,2,3,4-四氢-9H-咔唑-9-基) - 乙酸衍生物
- 专利标题: (3-amino-1,2,3,4-tetrahydro-9 H-carbazol-9-yl)-acetic acid derivatives
- 专利标题(中): (3-氨基-1,2,3,4-四氢-9H-咔唑-9-基) - 乙酸衍生物
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申请号: US12376932申请日: 2007-08-02
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公开(公告)号: US08143304B2公开(公告)日: 2012-03-27
- 发明人: Heinz Fretz , Julien Pothier , Philippe Risch
- 申请人: Heinz Fretz , Julien Pothier , Philippe Risch
- 申请人地址: CH Allschwil
- 专利权人: Actelion Pharmaceutical Ltd.
- 当前专利权人: Actelion Pharmaceutical Ltd.
- 当前专利权人地址: CH Allschwil
- 代理机构: Hunton & Williams LLP
- 优先权: WOPCT/IB2006/052723 20060807
- 国际申请: PCT/IB2007/053046 WO 20070802
- 国际公布: WO2008/017989 WO 20080214
- 主分类号: A01N43/38
- IPC分类号: A01N43/38 ; A61K31/40 ; C07C49/00 ; C07D209/94 ; C07D487/00 ; C07D491/00 ; C07D513/00
摘要:
The present invention relates to (3-amino-1,2,3,4-tetrahydro-9H-carbazol-9-yl)-acetic acid derivatives of Formula (I) wherein R1, R2, R3, R4, R5 and R6 are as described in the description and their use as prostaglandin receptor modulators, most particularly as prostaglandin D2 receptor modulators, in the treatment of various prostaglandin-mediated diseases and disorders, to pharmaceutical compositions containing these compounds and to processes for their preparation.
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