发明授权
- 专利标题: Taxane coatings for implantable medical devices
- 专利标题(中): 可植入医疗器械的紫杉烷涂层
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申请号: US12984733申请日: 2011-01-05
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公开(公告)号: US08147540B2公开(公告)日: 2012-04-03
- 发明人: Priscilla Reyes , William F. Moore , Patrick H. Ruane , Darin G. Schaeffer , Melinda S. Morrell
- 申请人: Priscilla Reyes , William F. Moore , Patrick H. Ruane , Darin G. Schaeffer , Melinda S. Morrell
- 申请人地址: US IN Bloomington
- 专利权人: Cook Medical Technologies LLC
- 当前专利权人: Cook Medical Technologies LLC
- 当前专利权人地址: US IN Bloomington
- 代理机构: Brinks Hofer Gilson & Lione
- 主分类号: A61F2/82
- IPC分类号: A61F2/82 ; A61F2/00 ; A61K31/335 ; A61M25/10
摘要:
This disclosure relates to implantable medical devices coated with a taxane therapeutic agent, such as paclitaxel, in one or more solid form(s) having varying dissolution rates. Particularly preferred coatings comprise amorphous and/or solvated solid forms of taxane therapeutic agents that provide durable coatings that release the taxane over a desired period of time, which can be varied in the absence of a polymer by selecting the type and amount of solid forms of the taxane therapeutic agent in the coating. Other preferred embodiments relate to methods of coating medical devices and methods of treatment. The coatings can provide a sustained release of the taxane therapeutic agent within a body vessel without containing a polymer to achieve the desired rate of paclitaxel elution.
公开/授权文献
- US20110153007A1 Taxane Coatings for Implantable Medical Devices 公开/授权日:2011-06-23