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    Methods of manufacturing and modifying taxane coatings for implantable medical devices
    4.
    发明授权
    Methods of manufacturing and modifying taxane coatings for implantable medical devices 有权
    制造和修饰可植入医疗器械的紫杉烷涂层的方法

    公开(公告)号：US07875284B2

    公开(公告)日：2011-01-25

    申请号：US11823283

    申请日：2007-06-27

    申请人： Priscilla Reyes ,  William F. Moore ,  Randy Joe Myers ,  Patrick H. Ruane ,  Melinda S. Morrell

    发明人： Priscilla Reyes ,  William F. Moore ,  Randy Joe Myers ,  Patrick H. Ruane ,  Melinda S. Morrell

    IPC分类号： A61F2/00

    CPC分类号： A61K31/335 ,  A61F2/0095 ,  A61F2/91 ,  A61F2250/0067 ,  A61F2250/0091

    摘要： This disclosure relates to endolumenal medical devices coated with a taxane therapeutic agent in one or more solid form(s) having varying dissolution rates. Particularly preferred coatings comprise amorphous paclitaxel, dihydrate paclitaxel, or combinations thereof that provide durable coatings that release paclitaxel over a desired period of time, which can be on the order of hours, days or weeks. Preferred embodiments relate to medical device coatings of paclitaxel, or paclitaxel analogs or derivatives, having one or more polymorph solid forms that provide a prolonged release of paclitaxel within a body vessel without requiring a polymer carrier or barrier layer to achieve the desired rate of paclitaxel elution.

    摘要翻译： 本公开涉及用一种或多种具有不同溶解速率的固体形式涂覆紫杉烷治疗剂的腔内医疗器械。 特别优选的涂层包括无定形紫杉醇，二水合紫杉醇或其组合，其提供耐久性涂层，其在期望的时间段内释放紫杉醇，其可以是数小时，数天或数周的数量级。 优选实施方案涉及具有一种或多种多晶型固体形式的紫杉醇或紫杉醇类似物或衍生物的医疗器械涂层，其提供紫杉醇在体内容器内的延长释放，而不需要聚合物载体或阻挡层来实现所需的紫杉醇洗脱速率 。

    CYCLODEXTRIN ELUTION MEDIA FOR MEDICAL DEVICE COATINGS COMPRISING A TAXANE THERAPEUTIC AGENT
    5.
    发明申请
    CYCLODEXTRIN ELUTION MEDIA FOR MEDICAL DEVICE COATINGS COMPRISING A TAXANE THERAPEUTIC AGENT 审中-公开
    用于包含TAXANE治疗剂的医疗装置涂层的环糊精溶液

    公开(公告)号：US20080286325A1

    公开(公告)日：2008-11-20

    申请号：US11774322

    申请日：2007-07-06

    申请人： Priscilla Reyes ,  Patrick H. Ruane ,  Melinda S. Morrell

    发明人： Priscilla Reyes ,  Patrick H. Ruane ,  Melinda S. Morrell

    IPC分类号： A61K9/00 ,  A61K31/337 ,  G01N33/15

    CPC分类号： A61K31/337 ,  A61L27/54 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/416 ,  Y10T436/142222

    摘要： The present disclosure provides methods of measuring the release of a taxane therapeutic agent from a medical device as a function time in contact with a suitable elution medium. The method preferably comprises the step of contacting a coated medical device comprising a taxane therapeutic agent with an elution medium comprising a cyclodextrin to provide an elution profile indicative of the composition or configuration of a medical device coating comprising a taxane therapeutic agent. The elution profile can provide information about the medical device coating that is useful in lot release testing.

    摘要翻译： 本公开提供了作为与合适的洗脱介质接触的功能时间从医疗装置测量紫杉烷治疗剂的释放的方法。 该方法优选包括使包含紫杉烷治疗剂的包被的医疗装置与包含环糊精的洗脱介质接触以提供指示包含紫杉烷治疗剂的医疗装置涂层的组成或构型的洗脱曲线的步骤。 洗脱曲线可以提供有关在批量释放测试中有用的医疗器械涂层的信息。

    Medical Devices Incorporating a Bioactive and Methods of Preparing Such Devices
    10.
    发明申请
    Medical Devices Incorporating a Bioactive and Methods of Preparing Such Devices 审中-公开
    纳入生物活性的医疗器械及其制备方法

    公开(公告)号：US20120027819A1

    公开(公告)日：2012-02-02

    申请号：US13251821

    申请日：2011-10-03

    申请人： Andrew P. Isch ,  Patrick H. Ruane ,  Waleska Pérez-Segarra

    发明人： Andrew P. Isch ,  Patrick H. Ruane ,  Waleska Pérez-Segarra

    IPC分类号： A61K9/00 ,  A61P23/00 ,  A61F2/82 ,  A61K31/445

    CPC分类号： A61L31/16 ,  A61L2300/402

    摘要： One embodiment provides a medical device comprising a base material and a bioactive in contact with the base material, the bioactive having a proton binding site with a non-ionic form and an ionic form, the bioactive being less soluble in water when the proton binding site is in the non-ionic form than when the proton binding site is in the ionic form, wherein at least 5% w/w of the bioactive is present with the proton binding site in the non-ionic form and wherein the bioactive is not an anesthetic. Another embodiment provides such a medical device where the bioactive is an anesthetic and where the device is not a ureteral stent. Another aspect provides method of manufacturing such devices.

    摘要翻译： 一个实施方案提供了包含基础材料和与基底材料接触的生物活性的医疗装置，所述生物活性物质具有非离子形式和离子形式的质子结合位点，当质子结合位点 与质子结合位点处于离子形式相比是非离子形式，其中至少5％w / w的生物活性存在于非离子形式的质子结合位点，并且其中生物活性物质不是 麻药。 另一个实施方案提供了这样的医疗装置，其中生物活性是麻醉剂，并且其中装置不是输尿管支架。 另一方面提供了制造这种装置的方法。