发明授权
US08153443B2 Characterization of the CBir1 antigenic response for diagnosis and treatment of Crohn's disease
有权
用于诊断和治疗克罗恩病的CBir1抗原应答的表征
- 专利标题： Characterization of the CBir1 antigenic response for diagnosis and treatment of Crohn's disease
- 专利标题（中）： 用于诊断和治疗克罗恩病的CBir1抗原应答的表征
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申请号： US12599549申请日： 2008-05-09
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公开(公告)号： US08153443B2公开(公告)日： 2012-04-10
- 发明人: Kent D. Taylor , Jerome I. Rotter , Charles O. Elson , Stephan R. Targan
- 申请人： Kent D. Taylor , Jerome I. Rotter , Charles O. Elson , Stephan R. Targan
- 申请人地址： US CA Los Angeles US AL Birmingham
- 专利权人： Cedars-Sinai Medical Center,The UAB Research Foundation
- 当前专利权人： Cedars-Sinai Medical Center,The UAB Research Foundation
- 当前专利权人地址： US CA Los Angeles US AL Birmingham
- 代理机构： Davis Wright Tremaine LLP
- 代理商 Sean D. Senn
- 国际申请： PCT/US2008/063202 WO 20080509
- 国际公布： WO2008/141148 WO 20081120
- 主分类号： G01N33/564
- IPC分类号： G01N33/564 ; C12Q1/68 ; A01N61/00 ; A61K31/00
摘要：
This invention provides methods of diagnosing or predicting susceptibility to Crohn's Disease by determining the presence or absence of genetic variants. In one embodiment, the present invention provides methods to diagnose and/or predict susceptibility to Crohn's Disease in an individual by determining the presence or absence of anti-Cbir1 reactivity and the presence or absence of TLR5 risk variants. In another embodiment, the present invention provides methods to diagnose Crohn's Disease by determining the presence or absence of NFKB1 haplotype H3 and/or ASCA expression. In another embodiment, the present invention provides methods of diagnosing Crohn's Disease by determining the presence or absence of Cbir1 specific peripheral blood T cell proliferation.
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