发明授权
- 专利标题： Pyrazolopyrimidine derivative
- 专利标题（中）： 吡唑并嘧啶衍生物
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申请号： US12442094申请日： 2007-09-14
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公开(公告)号： US08158638B2公开(公告)日： 2012-04-17
- 发明人: Satoru Ohsuki , Atsushi Tengeiji , Masahiro Ikeda , Yoshihiro Shibata , Chikahiro Nagata , Takashi Shimada
- 申请人： Satoru Ohsuki , Atsushi Tengeiji , Masahiro Ikeda , Yoshihiro Shibata , Chikahiro Nagata , Takashi Shimada
- 申请人地址： JP Tokyo
- 专利权人： Daiichi Sankyo Company, Limited
- 当前专利权人： Daiichi Sankyo Company, Limited
- 当前专利权人地址： JP Tokyo
- 代理机构： Christensen O'Connor Johnson Kindness PLLC
- 优先权： JP2006-253465 20060919
- 国际申请： PCT/JP2007/067933 WO 20070914
- 国际公布： WO2008/035629 WO 20080327
- 主分类号： A61K31/505
- IPC分类号： A61K31/505 ; A61K31/415 ; C07D491/00 ; C07D487/02
摘要：
Problem to be SolvedTo provide a novel compound inhibiting the effect of HSP90, in particular a novel compound inhibiting the function of HSP90 as a chaperone protein and having antitumor activity.SolutionThe present invention provides a pyrazolopyrimidine compound represented by the formula (1) having various substituents which inhibits the ATPase activity of HSP90 and which has antitumor activity, an HSP90 inhibitor comprising the compound represented by the formula (1), a medicament comprising the compound represented by the formula (1), an anticancer agent comprising the compound represented by the formula (1), a pharmaceutical composition comprising the compound represented by the formula (1) and a method for treating cancer using the compound represented by the formula (1).
公开/授权文献
- US20100113410A1 PYRAZOLOPYRIMIDINE DERIVATIVE 公开/授权日：2010-05-06
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