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公开(公告)号：US20240294610A1
公开(公告)日：2024-09-05
申请号：US18597675
申请日：2024-03-06
发明人： Daisuke Nishimiya , Ryuji Hashimoto , Toshiyuki Sato , Takako Kimura , Atsushi Yamasaki , Tatsuya Inoue
CPC分类号： C07K14/8135 , A61K48/005 , A61K49/0008 , A61P27/02 , C07K16/38 , C12N15/85 , C12Q1/37 , G01N2333/96433 , G01N2500/02
摘要： It is intended to provide a novel peptide. The present invention provides a peptide which comprises the amino acid sequence shown in SEQ ID NO: 30 and inhibits protease activity.
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公开(公告)号：US20240270803A1
公开(公告)日：2024-08-15
申请号：US18408527
申请日：2024-01-09
发明人： Tatsuya Inoue
摘要： To provide a novel pharmaceutical use of a peptide. A pharmaceutical composition for the treatment or prevention of retinitis pigmentosa, comprising a peptide which comprises the amino acid sequence shown in SEQ ID NO: 30 and inhibits a protease activity.
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公开(公告)号：US20240239778A1
公开(公告)日：2024-07-18
申请号：US18414072
申请日：2024-01-16
发明人： Keiji Saito , Katsuyoshi Nakajima , Yasuyuki Ogawa , Mitsuhiro Makino , Kaori Ito , Seiko Nagata , Makoto Hirasawa
IPC分类号： C07D413/14 , C07D307/94 , C07D309/12 , C07D405/10 , C07D405/14 , C07D407/12 , C07D413/10 , C07D498/10
CPC分类号： C07D413/14 , C07D307/94 , C07D309/12 , C07D405/10 , C07D405/14 , C07D407/12 , C07D413/10 , C07D498/10
摘要： The present invention addresses the problem of providing a compound for prophylaxis and/or treatment of central inflammatory diseases, or a pharmacologically acceptable salt thereof. The present invention addresses a compound of a general formula (I) or a pharmacologically acceptable salt thereof as a means to solve the problem. [R1: a C1-C6 alkyl group or the like, R2: a C1-C6 alkyl group or the like, A: a 5-membered aromatic hetero-ring or the like, R3, R3′: a C1-C6 alkyl group or the like]
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公开(公告)号：US12006372B2
公开(公告)日：2024-06-11
申请号：US17361137
申请日：2021-06-28
发明人： Kazuki Satoh , Kazuki Hirahara , Ichiro Watanabe , Masato Amano
IPC分类号： C07K16/28 , A61K39/395 , C07K16/32 , C12N1/20 , C12N5/10 , C12N5/12 , C12N15/02 , A61K39/00 , A61P35/00
CPC分类号： C07K16/32 , A61K39/395 , C07K16/28 , C12N1/20 , C12N5/10 , C12N5/12 , C12N15/02 , A61K2039/505 , A61P35/00 , C07K2317/51 , C07K2317/515 , C07K2317/565 , C07K2317/732 , C07K2317/92
摘要： The present invention relates to an antibody that binds to GARP and is useful as a therapeutic agent for a tumor, and a method for treating a tumor using the aforementioned antibody. It is an object of the present invention to provide an antibody, which inhibits the function of Treg in a tumor and is thereby used as a pharmaceutical product having therapeutic effects, a method for treating a tumor using the aforementioned antibody, and the like. An anti-GARP antibody that binds to GARP and exhibits inhibitory activity to Treg function and exhibits ADCC activity is obtained, and moreover a pharmaceutical composition for use in tumor therapy, comprising the aforementioned antibody, etc. is obtained.
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公开(公告)号：US20240150472A1
公开(公告)日：2024-05-09
申请号：US18550610
申请日：2022-03-16
发明人： Kazunori Yoshikiyo , Kazumichi Goto , Maki Tsujimoto , Chikako Nagasaki , Sayaka Yoshida , Hiroaki Tagaya
IPC分类号： C07K16/28 , A61K39/00 , A61P21/04 , C07K14/705 , C07K14/725 , C12N15/86
CPC分类号： C07K16/286 , A61K39/4611 , A61K39/4631 , A61K39/46433 , A61P21/04 , C07K14/7051 , C07K14/70517 , C07K14/70571 , C12N15/86 , C07K2319/02 , C07K2319/03 , C12N2740/15043
摘要： The present invention provides a chimeric polypeptide receptor in which an extracellular region comprising an antigenic region capable of being bound by an anti-human nicotinic acetylcholine receptor α1 subunit (nAChRα1) antibody, a transmembrane region, and an intracellular domain comprising an intracellular signaling domain are arranged in the presented order from the N-terminus towards the C-terminus, wherein an amino acid sequence of the antigenic region comprises the amino acid sequence as set forth in SEQ ID NO: 2 or an amino acid sequence derived from the amino acid sequence as set forth in SEQ ID NO: 2 by the substitution, deletion, insertion, and/or addition of one or several amino acids, a polynucleotide encoding the chimeric polypeptide receptor polypeptide, a cell expressing the chimeric polypeptide receptor, etc., which are useful in the treatment of myasthenia gravis.
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公开(公告)号：US20240150390A1
公开(公告)日：2024-05-09
申请号：US18263124
申请日：2022-01-31
发明人： Tomokazu OGURA , Takeshi NAKAYA , Hidekazu INOUE , Narumi ABE , Yuzo ABE , Tatsuya NAKAMURA , Yuko YAMAMOTO , Kohei SAKANISHI , Tatsuhiro SAKAMOTO , Satoshi NAKANE
IPC分类号： C07H19/213 , A61K47/68
CPC分类号： C07H19/213 , A61K47/6851 , A61K47/6873
摘要： The purpose of the present invention is to provide a novel stereoselective method for preparing a cyclic dinucleotide derivative and a production intermediate therefor, which can be used for an antibody-immunostimulant conjugate. Also provided is a method for producing a cyclic dinucleotide-linker and an antibody-immunostimulant conjugate while using the above production method. Further provided is a method for preparing a cyclic dinucleotide derivative, the method including the step of subjecting a compound (I) and a compound (IV) to stereoselective condensation using an optically active phosphitylating agent (Rc-II) or (Sc-II).
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公开(公告)号：US20240115721A1
公开(公告)日：2024-04-11
申请号：US18272050
申请日：2022-01-13
申请人： MEMORIAL SLOAN KETTERING CANCER CENTER , TRI-INSTITUTIONAL THERAPEUTICS DISCOVERY INSTITUTE , DAIICHI SANKYO COMPANY, LIMITED
发明人： John T. POIRIER , Charles RUDIN , Jason LEWIS , Abdul KHAN , David ANDREW , Xinlei CHEN , Ivo LORENZ , Hironori MATSUNAGA
CPC分类号： A61K47/68037 , A61K47/6851 , A61P35/00 , C07K16/28
摘要： It is an object of the present invention to provide an antibody-drug conjugate of an antibody binding to DLL3 and a drug having antitumor activity, a pharmaceutical composition comprising the antibody-drug conjugate and having therapeutic effects on a tumor, a method for treating a tumor using the antibody-drug conjugate or the pharmaceutical composition, and the like. The present invention provides an antibody-drug conjugate of an antibody binding to DLL3 and a drug having antitumor activity, a pharmaceutical composition comprising the antibody or the antibody-drug conjugate, and a method for treating a tumor.
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公开(公告)号：US11952423B2
公开(公告)日：2024-04-09
申请号：US18318610
申请日：2023-05-16
发明人： Hiroshi Shiku , Yasushi Akahori , Kento Tanaka , Ayaka Yatsu , Junya Ichikawa , Toshiaki Ohtsuka , Shiho Kozuma , Ryuji Hashimoto , Makiko Nakayama , Naoya Shinozaki , Kensuke Nakamura , Ichiro Watanabe , Shinji Furuzono
CPC分类号： C07K16/2809 , C07K16/32 , C07K2317/31 , C07K2317/52 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/528 , C07K2317/53 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622
摘要： A novel antibody that can be used as an anti-tumor agent and an anti-tumor agent that comprises, as an active ingredient, a molecule containing such an antibody.
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公开(公告)号：US20230382856A1
公开(公告)日：2023-11-30
申请号：US18249421
申请日：2021-10-29
IPC分类号： C07D209/08 , C07D209/18 , C07D413/06
CPC分类号： C07D209/08 , C07D209/18 , C07D413/06
摘要： The present inventors found a novel method for reducing formyl groups with the use of a Lewis acid and a hydride reducing agent in a production method for a 3-methyl-4-haloindole derivative. The present inventors also found that demethylation and/or dehalogenation of the derivative are suppressed by this method, making post-treatment easier or the derivative obtained at a high yield.
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公开(公告)号：US11806339B2
公开(公告)日：2023-11-07
申请号：US17734875
申请日：2022-05-02
发明人： Takeshi Jimbo
IPC分类号： A61K31/444 , A61P35/00 , A61K31/506
CPC分类号： A61K31/444 , A61K31/506 , A61P35/00
摘要： The present invention provides a medicament comprising a compound represented by general formula (1) which has Axl inhibitory activity, and an EGFR tyrosine kinase inhibitor in combination, and a method for treating cancer using this combination. The present invention provides an excellent medicament and method for treating cancer which is highly effective for inhibiting resistance to an EGFR tyrosine kinase inhibitor in cancer treatment, and causes less adverse reactions such as weight loss.
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