发明授权
US08158648B2 Heteroaryl 11-beta hydroxysteroid dehydrogenase type I inhibitors
有权
杂芳基11-β羟基类固醇脱氢酶I型抑制剂
- 专利标题： Heteroaryl 11-beta hydroxysteroid dehydrogenase type I inhibitors
- 专利标题（中）： 杂芳基11-β羟基类固醇脱氢酶I型抑制剂
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申请号： US12509541申请日： 2009-07-27
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公开(公告)号： US08158648B2公开(公告)日： 2012-04-17
- 发明人: James J. Li , Lawrence G. Hamann , Haixia Wang
- 申请人： James J. Li , Lawrence G. Hamann , Haixia Wang
- 代理商 Terence J. Bogie
- 主分类号： A01N43/42
- IPC分类号： A01N43/42 ; A61K31/44 ; C07D491/02 ; C07D498/02
摘要：
Novel compounds are provided which are 11-beta-hydroxysteroid dehydrogenase type I inhibitors. 11-beta-hydroxysteroid dehydrogenase type I inhibitors are useful in treating, preventing, or slowing the progression of diseases requiring 11-beta-hydroxysteroid dehydrogenase type I inhibitor therapy. These novel compounds have the structure: W-L-Z (I) or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein W, L and Z are defined herein.