Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates and methods of making said conjugates

发明授权

US08163888B2 Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates and methods of making said conjugates 有权

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专利标题： Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates and methods of making said conjugates
申请号： US11927217

申请日： 2007-10-29
公开(公告)号： US08163888B2

公开(公告)日： 2012-04-24
发明人: Rita M. Steeves , Ravi V. J. Chari , Walter A. Blattler
申请人： Rita M. Steeves , Ravi V. J. Chari , Walter A. Blattler
申请人地址： US MA Waltham
专利权人： Immunogen, Inc.
当前专利权人： Immunogen, Inc.
当前专利权人地址： US MA Waltham
代理机构： Sughrue Mion, PLLC
主分类号： C07K16/00
IPC分类号： C07K16/00

Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates and methods of making said conjugates

摘要：

The present invention discloses a method for targeting maytansinoids to a selected cell population, the method comprising contacting a cell population or tissue suspected of containing the selected cell population with a cell-binding agent maytansinoid conjugate, wherein one or more maytansinoids is covalently linked to the cell-binding agent via a non-cleavable linker and the cell-binding agent binds to cells of the selected cell population.

公开/授权文献

US20080114153A1 METHOD OF TARGETING SPECIFIC CELL POPULATIONS USING CELL-BINDING AGENT MAYTANSINOID CONJUGATES LINKED VIA A NON-CLEAVABLE LINKER, SAID CONJUGATES AND METHODS OF MAKING SAID CONJUGATES 公开/授权日：2008-05-15

信息查询

Espacenet

IPC分类:

C	化学；冶金
C07	有机化学
C07K	肽（含有β-内酰胺的肽入C07D；在分子中除了形成本身的肽环外不含有任何其他的肽键的环状二肽，如哌嗪-2,5-二酮入C07D；环肽型麦角生物碱入C07D519/02；单细胞蛋白质、酶入C12N；获得肽的基因工程方法入C12N15/00）
C07K16/00	免疫球蛋白，例如，单克隆或多克隆抗体