发明授权
US08168168B2 Infectivity-enhanced conditionally-replicative adenovirus and uses thereof
有权
感染性增强的条件复制型腺病毒及其用途
- 专利标题： Infectivity-enhanced conditionally-replicative adenovirus and uses thereof
- 专利标题（中）： 感染性增强的条件复制型腺病毒及其用途
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申请号： US12636134申请日： 2009-12-11
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公开(公告)号： US08168168B2公开(公告)日： 2012-05-01
- 发明人: Juan Fueyo , Candelaria Gomez-Manzano
- 申请人： Juan Fueyo , Candelaria Gomez-Manzano
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; C12N15/34 ; C12N7/00
摘要：
A modified adenovirus capable of overcoming the problem of low level of coxsackie-adenovirus receptor (CAR) expression on tumor cells and methods of using such adenovirus are provided. The fiber protein of the adenovirus is modified by insertion or replacement so as to target the adenovirus to tumor cells, and the replication of the modified adenovirus is limited to tumor cells due to specific promoter control or mutations in E1a or E1b genes.
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