Invention Grant
US08168177B2 Method of regulating mammalian target-of-rapamycin activity by interaction between phospholipase D and Rheb
失效
通过磷脂酶D和Rheb之间的相互作用调节哺乳动物雷帕霉素活性的方法
- Patent Title: Method of regulating mammalian target-of-rapamycin activity by interaction between phospholipase D and Rheb
- Patent Title (中): 通过磷脂酶D和Rheb之间的相互作用调节哺乳动物雷帕霉素活性的方法
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Application No.: US12374239Application Date: 2007-08-03
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Publication No.: US08168177B2Publication Date: 2012-05-01
- Inventor: Sung-Ho Ryu , Pann-Ghill Suh , Sang-Hoon Ha , Mi-Nam Lee , Hyun-Ju Lee , Il-Shin Kim , Do-Hyung Kim , Tae-Hoon Lee
- Applicant: Sung-Ho Ryu , Pann-Ghill Suh , Sang-Hoon Ha , Mi-Nam Lee , Hyun-Ju Lee , Il-Shin Kim , Do-Hyung Kim , Tae-Hoon Lee
- Applicant Address: KR Pohang
- Assignee: Postech Academy-Industry Foundation
- Current Assignee: Postech Academy-Industry Foundation
- Current Assignee Address: KR Pohang
- Agency: Marshall, Gerstein & Borun LLP
- International Application: PCT/KR2007/003754 WO 20070803
- International Announcement: WO2008/016282 WO 20080207
- Main IPC: A61K38/46
- IPC: A61K38/46 ; C12N9/14
Abstract:
The present invention relates to method of regulating mammalian target-of-rapamycin (mTOR) based on a novel finding of a regulating mechanism of mTOR by a phospholipase D (PLD), and Ras homolog enriched in brain (Rheb). Further, the present invention also relates to a method of screening inhibitors of mTOR, and a method and a composition for treating mTOR-related metabolic diseases by inhibiting mTOR.
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