-
1.发明授权Method of regulating mammalian target-of-rapamycin activity by interaction between phospholipase D and raptor 失效通过磷脂酶D和猛禽相互作用调节哺乳动物雷帕霉素活性的方法公开(公告)号：US08278263B2
公开(公告)日：2012-10-02
申请号：US12374262
申请日：2007-08-03
申请人： Sung-Ho Ryu , Pann-Ghill Suh , Sang-Hoon Ha , Do-Hyung Kim , Il-Shin Kim , Jung-Hwan Kim , Mi-Nam Lee , Hyun-Ju Lee , Jong Heon Kim , Sung-Key Jang , Tae-Hoon Lee
发明人： Sung-Ho Ryu , Pann-Ghill Suh , Sang-Hoon Ha , Do-Hyung Kim , Il-Shin Kim , Jung-Hwan Kim , Mi-Nam Lee , Hyun-Ju Lee , Jong Heon Kim , Sung-Key Jang , Tae-Hoon Lee
IPC分类号： A61K38/02
CPC分类号： A61K38/1709 , C07K14/4702 , C12N9/20 , C12Y301/04004 , G01N33/5011 , G01N2333/9121 , G01N2333/916
摘要： The present invention relates to a method of regulating mammalian target-of-rapamycin (mTOR) by regulating a phospholipase D (PLD) activity that generates a complex with mTOR. Further, the present invention also relates to a method of screening inhibitors of mTOR, and a method and a composition for treating mTOR-related metabolic diseases by inhibiting mTOR.
摘要翻译： 本发明涉及通过调节与mTOR产生复合物的磷脂酶D（PLD）活性来调节哺乳动物雷帕霉素靶（mTOR）的方法。 此外，本发明还涉及一种筛选mTOR抑制剂的方法，以及通过抑制mTOR来治疗mTOR相关代谢疾病的方法和组合物。
-
2.发明授权Method of regulating mammalian target-of-rapamycin activity by interaction between phospholipase D and Rheb 失效通过磷脂酶D和Rheb之间的相互作用调节哺乳动物雷帕霉素活性的方法公开(公告)号：US08168177B2
公开(公告)日：2012-05-01
申请号：US12374239
申请日：2007-08-03
申请人： Sung-Ho Ryu , Pann-Ghill Suh , Sang-Hoon Ha , Mi-Nam Lee , Hyun-Ju Lee , Il-Shin Kim , Do-Hyung Kim , Tae-Hoon Lee
发明人： Sung-Ho Ryu , Pann-Ghill Suh , Sang-Hoon Ha , Mi-Nam Lee , Hyun-Ju Lee , Il-Shin Kim , Do-Hyung Kim , Tae-Hoon Lee
CPC分类号： C12Q1/485 , A61K38/00 , C12N9/16 , C12Q1/34 , G01N2333/9121 , G01N2333/916
摘要： The present invention relates to method of regulating mammalian target-of-rapamycin (mTOR) based on a novel finding of a regulating mechanism of mTOR by a phospholipase D (PLD), and Ras homolog enriched in brain (Rheb). Further, the present invention also relates to a method of screening inhibitors of mTOR, and a method and a composition for treating mTOR-related metabolic diseases by inhibiting mTOR.
摘要翻译： 本发明涉及基于由磷脂酶D（PLD）和富含脑（Rheb）的Ras同源物的mTOR调节机制的新发现调节哺乳动物雷帕霉素靶（mTOR）的方法。 此外，本发明还涉及一种筛选mTOR抑制剂的方法，以及通过抑制mTOR来治疗mTOR相关代谢疾病的方法和组合物。
-
3.发明申请Method of Regulating Mammalian Target-of-Rapamycin Activity by Interaction Between Phospholipase D and Raptor 失效通过磷脂酶D和猛禽相互作用调节哺乳动物雷帕霉素目标的方法公开(公告)号：US20100184636A1
公开(公告)日：2010-07-22
申请号：US12374262
申请日：2007-08-03
申请人： Sung-Ho Ryu , Pann-Ghill Suh , Sang-Hoon Ha , Do-Hyung Kim , Il-Shin Kim , Jung-Hwan Kim , Mi-Nam Lee , Hyun-Ju Lee , Jong-Heon Kim , Sung-Key Jang , Tae-Hoon Lee
发明人： Sung-Ho Ryu , Pann-Ghill Suh , Sang-Hoon Ha , Do-Hyung Kim , Il-Shin Kim , Jung-Hwan Kim , Mi-Nam Lee , Hyun-Ju Lee , Jong-Heon Kim , Sung-Key Jang , Tae-Hoon Lee
CPC分类号： A61K38/1709 , C07K14/4702 , C12N9/20 , C12Y301/04004 , G01N33/5011 , G01N2333/9121 , G01N2333/916
摘要： The present invention relates to a method of regulating mammalian target-of-rapamycin (mTOR) by regulating a phospholipase D (PLD) activity that generates a complex with mTOR. Further, the present invention also relates to a method of screening inhibitors of mTOR, and a method and a composition for treating mTOR-related metabolic diseases by inhibiting mTOR.
摘要翻译： 本发明涉及通过调节与mTOR产生复合物的磷脂酶D（PLD）活性来调节哺乳动物雷帕霉素靶（mTOR）的方法。 此外，本发明还涉及一种筛选mTOR抑制剂的方法，以及通过抑制mTOR来治疗mTOR相关代谢疾病的方法和组合物。
-
4.发明申请Method of Regulating Mammalian Target-of-Rapamycin Activity by Interaction Between Phospholipase D and RHEB 失效通过磷脂酶D和RHEB之间的相互作用调节哺乳动物雷帕霉素目标的方法公开(公告)号：US20090304667A1
公开(公告)日：2009-12-10
申请号：US12374239
申请日：2007-08-03
申请人： Sung-Ho Ryu , Pann-Ghill Suh , Sang-Hoon Ha , Mi-Nam Lee , Hyun-Ju Lee , II-Shin Kim , Do-Hyung Kim , Tae-Hoon Lee
发明人： Sung-Ho Ryu , Pann-Ghill Suh , Sang-Hoon Ha , Mi-Nam Lee , Hyun-Ju Lee , II-Shin Kim , Do-Hyung Kim , Tae-Hoon Lee
IPC分类号： A61K38/46 , A61K38/16 , G01N33/567 , G01N33/574
CPC分类号： C12Q1/485 , A61K38/00 , C12N9/16 , C12Q1/34 , G01N2333/9121 , G01N2333/916
摘要： The present invention relates to method of regulating mammalian target-of-rapamycin (mTOR) based on a novel finding of a regulating mechanism of mTOR by a phospholipase D (PLD), and Ras homolog enriched in brain (Rheb). Further, the present invention also relates to a method of screening inhibitors of mTOR, and a method and a composition for treating mTOR-related metabolic diseases by inhibitin mTOR.
摘要翻译： 本发明涉及基于由磷脂酶D（PLD）和富含脑（Rheb）的Ras同源物的mTOR调节机制的新发现调节哺乳动物雷帕霉素靶（mTOR）的方法。 此外，本发明还涉及一种筛选mTOR抑制剂的方法，以及通过抑制mTOR治疗mTOR相关代谢疾病的方法和组合物。
-
-
-
搜索结果
4 条记录 (耗时 0.035 秒)
