Invention Grant
US08168835B2 Method for preparing propargylic alcohol catalyzed by 2-morpholinoisobornane-10-thiol
有权
由2-吗啉代异硼烷-10-硫醇催化制备炔丙醇的方法
- Patent Title: Method for preparing propargylic alcohol catalyzed by 2-morpholinoisobornane-10-thiol
- Patent Title (中): 由2-吗啉代异硼烷-10-硫醇催化制备炔丙醇的方法
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Application No.: US12787961Application Date: 2010-05-26
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Publication No.: US08168835B2Publication Date: 2012-05-01
- Inventor: Biing-Jiun Uang , Ping-Yu Wu , Hsyueh-Liang Wu
- Applicant: Biing-Jiun Uang , Ping-Yu Wu , Hsyueh-Liang Wu
- Applicant Address: TW Hsinchu
- Assignee: National Tsing Hua University
- Current Assignee: National Tsing Hua University
- Current Assignee Address: TW Hsinchu
- Agency: Muncy, Geissler, Olds & Lowe, PLLC
- Main IPC: C07C41/18
- IPC: C07C41/18 ; C07C29/36
Abstract:
A method for preparing a propargylic alcohol catalyzed by 2-morpholinoisobornane-10-thiol (MITH) is disclosed, which includes reacting R1CHO with R2CCH in the presence of R3ZnR4 and MITH, wherein each of R1, R2, R3, and R4, independently, is optionally substituted alkyl, alkenyl, cycloalkyl, cycloalkenyl, alkylsilyl, heterocycloalkyl, heterocycloalkenyl, aryl, aryloxy, or heteroaryl. The method can give enantioenriched propargylic alcohols with good enantioselective at low loading of MITH.
Public/Granted literature
- US20110295042A1 METHOD FOR PREPARING PROPARGYLIC ALCOHOL CATALYZED BY 2-MORPHOLINOISOBORNANE-10-THIOL Public/Granted day:2011-12-01
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