Invention Grant
US08173366B2 Genetic changes in ATM and ATR/CHEK1 as prognostic indicators in cancer
有权
ATM和ATR / CHEK1作为癌症预后指标的遗传变化
- Patent Title: Genetic changes in ATM and ATR/CHEK1 as prognostic indicators in cancer
- Patent Title (中): ATM和ATR / CHEK1作为癌症预后指标的遗传变化
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Application No.: US12586052Application Date: 2009-09-15
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Publication No.: US08173366B2Publication Date: 2012-05-08
- Inventor: Susanne M. Gollin , Rahul Atul Parikh , Xin Huang
- Applicant: Susanne M. Gollin , Rahul Atul Parikh , Xin Huang
- Applicant Address: US PA Pittsburgh
- Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
- Current Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
- Current Assignee Address: US PA Pittsburgh
- Agency: Baker Botts, LLP
- Main IPC: C12Q1/68
- IPC: C12Q1/68
Abstract:
The present invention relates to the discovery that, in human cancer, an 11q deletion of ATM together with an increase in ATR and CHEK1 expression correlates with resistance to ionizing radiation which could be overcome by inhibition of the ATR/CHEK1 pathway. It provides for methods of identifying patients unlikely to exhibit an adequate response to radiation therapy and/or chemotherapy who may benefit from ATR/CHEK1 pathway inhibition, as well as methods of treating said patients.
Public/Granted literature
- US20100173971A1 Genetic changes in ATM and ATR/CHEK1 as prognostic indicators in cancer Public/Granted day:2010-07-08
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