The present disclosure describes a system and method for multi-host extension of a single-host device comprising a network switch fabric that comprises a rooted hierarchical bus, a first compute node coupled to the network switch fabric, and an input/output (I/O) node coupled to the network switch fabric, the I/O node comprising a network switch fabric interface and a real single-host device. The network switch fabric interface creates a first virtual device mapped to the real single-host device. The first virtual device allows the first compute node to access the real single-host device.