发明授权
US08178541B2 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
有权
8- [3-氨基 - 哌啶-1-基] - 黄嘌呤，其制备及其作为药物组合物的用途
![8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions](/docs/US/2012-05-15/US08178541B2/abs.jpg.600x600.jpg)
- 专利标题： 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
- 专利标题（中）： 8- [3-氨基 - 哌啶-1-基] - 黄嘌呤，其制备及其作为药物组合物的用途
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申请号： US12143128申请日： 2008-06-20
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公开(公告)号： US08178541B2公开(公告)日： 2012-05-15
- 发明人: Frank Himmelsbach , Elke Langkopf , Matthias Eckhardt , Michael Mark , Roland Maier , Ralf Lotz , Mohammad Tadayyon
- 申请人： Frank Himmelsbach , Elke Langkopf , Matthias Eckhardt , Michael Mark , Roland Maier , Ralf Lotz , Mohammad Tadayyon
- 申请人地址： DE Ingelheim am Rhein
- 专利权人： Boehringer Ingelheim Pharma GmbH & Co. KG
- 当前专利权人： Boehringer Ingelheim Pharma GmbH & Co. KG
- 当前专利权人地址： DE Ingelheim am Rhein
- 代理商 Michael P. Morris; David L. Kershner
- 优先权： DE10238243 20020821; DE10312353 20030320
- 主分类号： A61K31/522
- IPC分类号： A61K31/522 ; A61P3/10 ; A61P3/04 ; C07D473/06 ; C07D519/00 ; A61P19/02
![8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions](/abs-image/US/2012/05/15/US08178541B2/abs.jpg.150x150.jpg)
摘要：
The present invention relates to substituted xanthines of general formula wherein R1 to R3 are as defined herein, the tautomers, the stereoisomers, the mixtures, the prodrugs thereof and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).