发明授权
- 专利标题： Compounds and compositions as hedgehog pathway modulators
- 专利标题（中）： 化合物和组合物作为刺猬蛋白通路调节剂
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申请号： US12299290申请日： 2007-05-04
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公开(公告)号： US08178563B2公开(公告)日： 2012-05-15
- 发明人: Wenqi Gao , Jiqing Jiang , Yongqin Wan , Dai Cheng , Dong Han , Xu Wu , Shifeng Pan
- 申请人： Wenqi Gao , Jiqing Jiang , Yongqin Wan , Dai Cheng , Dong Han , Xu Wu , Shifeng Pan
- 申请人地址： BM Hamilton
- 专利权人： IRM LLC
- 当前专利权人： IRM LLC
- 当前专利权人地址： BM Hamilton
- 代理机构： Genomics Institute of the Novartis Research Foundation
- 代理商 Chihang Amy Smith
- 国际申请： PCT/US2007/068292 WO 20070504
- 国际公布： WO2007/131201 WO 20071115
- 主分类号： A61K31/44
- IPC分类号： A61K31/44 ; C07D213/72
摘要：
The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.