发明授权
- 专利标题： Anti-ferroportin 1 monoclonal antibodies and uses thereof
- 专利标题（中）： 抗铁结蛋白1单克隆抗体及其用途
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申请号： US12628263申请日： 2009-12-01
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公开(公告)号： US08183346B2公开(公告)日： 2012-05-22
- 发明人: Donmienne Doen Mun Leung , Peng Luan , Joseph Vincent Manetta , Ying Tang , Derrick Ryan Witcher
- 申请人： Donmienne Doen Mun Leung , Peng Luan , Joseph Vincent Manetta , Ying Tang , Derrick Ryan Witcher
- 申请人地址： US IN Indianapolis
- 专利权人： Eli Lilly and Company
- 当前专利权人： Eli Lilly and Company
- 当前专利权人地址： US IN Indianapolis
- 代理商 Robert L. Sharp
- 主分类号： C07K16/00
- IPC分类号： C07K16/00 ; C07K16/28 ; C07K16/46
摘要：
Provided are monoclonal antibodies and antigen-binding fragments thereof that bind to, and inhibit the activity of human FPN1, and which are effective in maintaining or increasing the transport of iron out of mammalian cells and/or maintaining or increasing the level of serum iron, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a subject in vivo.
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