发明授权
- 专利标题: High activity growth factor mutants
- 专利标题(中): 高活性生长因子突变体
-
申请号: US12094227申请日: 2006-11-17
-
公开(公告)号: US08188226B2公开(公告)日: 2012-05-29
- 发明人: Jens Pohl , Frank Ploeger , Michael Kruse
- 申请人: Jens Pohl , Frank Ploeger , Michael Kruse
- 申请人地址: DE Heidelberg
- 专利权人: Biopharm Gesellschaft zur biotechnologischen Entwicklung von Pharmaka mbH
- 当前专利权人: Biopharm Gesellschaft zur biotechnologischen Entwicklung von Pharmaka mbH
- 当前专利权人地址: DE Heidelberg
- 代理机构: Rothwell, Figg, Ernst & Manbeck, P.C.
- 优先权: EP05025261 20051118
- 国际申请: PCT/EP2006/011074 WO 20061117
- 国际公布: WO2007/057212 WO 20070524
- 主分类号: C07K14/51
- IPC分类号: C07K14/51 ; A61K38/18 ; C07H21/04 ; C12N15/00 ; C12N1/21 ; C12P21/00
摘要:
The application relates to novel biosynthetic growth factor mutants, derived from GDF-5, which exhibit improved biological activity. Mutations at positions 453 and 456 of human GDF-5 are disclosed, as well as use of these mutants in therapy of diseases associated with tissue degeneration/destruction.
公开/授权文献
- US20080318860A1 High Activity Growth Factor Mutants 公开/授权日:2008-12-25
信息查询