发明授权
- 专利标题： Process for production of lasofoxifene or analogue thereof
- 专利标题（中）： 雷诺昔芬或其类似物的生产方法
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申请号： US12162068申请日： 2007-01-25
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公开(公告)号： US08193394B2公开(公告)日： 2012-06-05
- 发明人: Isamu Shiina , Yoshiyuki Sano , Kenya Nakata
- 申请人： Isamu Shiina , Yoshiyuki Sano , Kenya Nakata
- 申请人地址： JP Tokyo
- 专利权人： Tokyo University of Science Educational Foundation Administrative Organization
- 当前专利权人： Tokyo University of Science Educational Foundation Administrative Organization
- 当前专利权人地址： JP Tokyo
- 代理机构： Scully, Scott, Murphy & Presser, P.C.
- 优先权： JP2006-018079 20060126; JP2007-001114 20070109
- 国际申请： PCT/JP2007/051186 WO 20070125
- 国际公布： WO2007/086471 WO 20070802
- 主分类号： C07C33/02
- IPC分类号： C07C33/02
摘要：
Disclosed is a novel process for production of lasofoxifene, nafoxidine or an analogue thereof, which comprises reduced number of reaction steps, has a high efficiency, and is practically advantageous. For the production of lasofoxifene or an analogue thereof, a compound represented by the formula (4) is used as an intermediate. The compound represented by the formula (4) can be produced using compounds represented by the formulae (1) to (3) as starting compounds by performing the coupling of the three components in one step.
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