发明授权
US08198272B2 Triazolium salts as PAR1 inhibitors, production thereof, and use as medicaments
有权
作为PAR1抑制剂的三唑鎓盐，其制备和用作药物
- 专利标题： Triazolium salts as PAR1 inhibitors, production thereof, and use as medicaments
- 专利标题（中）： 作为PAR1抑制剂的三唑鎓盐，其制备和用作药物
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申请号： US12851219申请日： 2010-08-05
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公开(公告)号： US08198272B2公开(公告)日： 2012-06-12
- 发明人: Uwe Heinelt , Volkmar Wehner , Matthias Herrmann , Karl Schoenafinger , Henning Steinhagen
- 申请人： Uwe Heinelt , Volkmar Wehner , Matthias Herrmann , Karl Schoenafinger , Henning Steinhagen
- 申请人地址： FR Paris
- 专利权人： Sanofi-Aventis
- 当前专利权人： Sanofi-Aventis
- 当前专利权人地址： FR Paris
- 代理商 Kelly L. Bender
- 优先权： EP08290114 20080205
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; C07D413/10 ; A61K31/5025 ; A61K31/5355 ; A61P7/00 ; A61P9/10 ; A61P29/00 ; A61P37/08 ; A61P3/14
摘要：
The invention relates to novel compounds of formula I where X, A−, Q1, Q2, Q3, R2, R3, R4, R5, R6, R7, R8 and R9 are each as defined below. The compounds of formula I have antithrombotic activity and inhibit especially protease-activated receptor 1 (PAR1). The invention further relates to a process for preparing the compound of formula I and to the use thereof as a medicament.
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