Invention Grant
US08198272B2 Triazolium salts as PAR1 inhibitors, production thereof, and use as medicaments
有权
作为PAR1抑制剂的三唑鎓盐，其制备和用作药物
- Patent Title: Triazolium salts as PAR1 inhibitors, production thereof, and use as medicaments
- Patent Title (中): 作为PAR1抑制剂的三唑鎓盐，其制备和用作药物
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Application No.: US12851219Application Date: 2010-08-05
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Publication No.: US08198272B2Publication Date: 2012-06-12
- Inventor: Uwe Heinelt , Volkmar Wehner , Matthias Herrmann , Karl Schoenafinger , Henning Steinhagen
- Applicant: Uwe Heinelt , Volkmar Wehner , Matthias Herrmann , Karl Schoenafinger , Henning Steinhagen
- Applicant Address: FR Paris
- Assignee: Sanofi-Aventis
- Current Assignee: Sanofi-Aventis
- Current Assignee Address: FR Paris
- Agent Kelly L. Bender
- Priority: EP08290114 20080205
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D413/10 ; A61K31/5025 ; A61K31/5355 ; A61P7/00 ; A61P9/10 ; A61P29/00 ; A61P37/08 ; A61P3/14
Abstract:
The invention relates to novel compounds of formula I where X, A−, Q1, Q2, Q3, R2, R3, R4, R5, R6, R7, R8 and R9 are each as defined below. The compounds of formula I have antithrombotic activity and inhibit especially protease-activated receptor 1 (PAR1). The invention further relates to a process for preparing the compound of formula I and to the use thereof as a medicament.
Public/Granted literature
- US20110034452A1 TRIAZOLIUM SALTS AS PAR1 INHIBITORS, PRODUCTION THEREOF, AND USE AS MEDICAMENTS Public/Granted day:2011-02-10
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