发明授权
- 专利标题: Ovr115 antibody compositions and methods of use
- 专利标题(中): Ovr115抗体组合物和使用方法
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申请号: US10556478申请日: 2004-05-17
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公开(公告)号: US08207311B2公开(公告)日: 2012-06-26
- 发明人: Glenn Pilkington , Gilbert-Andre Keller , Wenlu Li , Laura Corral , Iris Simon
- 申请人: Glenn Pilkington , Gilbert-Andre Keller , Wenlu Li , Laura Corral , Iris Simon
- 申请人地址: US CA South San Francisco
- 专利权人: diaDexus, Inc.
- 当前专利权人: diaDexus, Inc.
- 当前专利权人地址: US CA South San Francisco
- 代理机构: Licata & Tyrrell P.C.
- 代理商 Keith R. McCollum
- 国际申请: PCT/US2004/015258 WO 20040517
- 国际公布: WO2004/104173 WO 20041202
- 主分类号: C07K16/00
- IPC分类号: C07K16/00 ; C07K17/00 ; C07K17/14 ; C12P21/08 ; A61K39/395 ; A61K39/00 ; G01N33/53 ; G01N33/574 ; C12N5/07 ; C12N5/16
摘要:
The invention provides isolated anti-ovarian, pancreatic, lung or breast cancer antigen (Ovr115) antibodies that bind to Ovr115 on a mammalian cell in vivo. The invention also encompasses compositions comprising an anti-Ovr115 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Ovr115 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-Ovr115 antibodies. The invention encompasses a method of producing the anti-Ovr115 antibodies. Other aspects of the invention are a method of killing an Ovr115-expressing cancer cell, comprising contacting the cancer cell with an anti-Ovr115 antibody and a method of alleviating or treating an Ovr115-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-Ovr115 antibody to the mammal.
公开/授权文献
- US20070104647A1 Ovr115 antibody compositions and methods of use 公开/授权日:2007-05-10
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