发明授权
US08211859B2 α-galactoceramide analogs, their methods of manufacture, intermediate compounds useful in these methods, and pharmaceutical compositions containing them
失效
α-半乳糖苷类似物，其制造方法，可用于这些方法的中间体化合物和含有它们的药物组合物
- 专利标题： α-galactoceramide analogs, their methods of manufacture, intermediate compounds useful in these methods, and pharmaceutical compositions containing them
- 专利标题（中）： α-半乳糖苷类似物，其制造方法，可用于这些方法的中间体化合物和含有它们的药物组合物
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申请号： US12446431申请日： 2007-10-18
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公开(公告)号： US08211859B2公开(公告)日： 2012-07-03
- 发明人: Didier Dubreuil , Muriel Pipelier , Laurent Micouin , Thomas Lecourt , Vivien Lacone , Marc Bonneville , Jacques Lependu , Anne-Laure Turcot-Dubois
- 申请人： Didier Dubreuil , Muriel Pipelier , Laurent Micouin , Thomas Lecourt , Vivien Lacone , Marc Bonneville , Jacques Lependu , Anne-Laure Turcot-Dubois
- 申请人地址： FR Paris FR Paris FR Paris
- 专利权人： Centre National de la Recherche Scientifique,Universite Paris Descartes,Institut National de la Sante et de la Recherche Medicale (INSERM)
- 当前专利权人： Centre National de la Recherche Scientifique,Universite Paris Descartes,Institut National de la Sante et de la Recherche Medicale (INSERM)
- 当前专利权人地址： FR Paris FR Paris FR Paris
- 代理机构： Morgan, Lewis & Bockius LLP
- 优先权： WOPCT/IB2006/003929 20061018
- 国际申请： PCT/IB2007/004270 WO 20071018
- 国际公布： WO2008/047249 WO 20080424
- 主分类号： A01N43/04
- IPC分类号： A01N43/04 ; A61K31/70
摘要：
The invention relates to α-galactoceramide analogs, their methods of manufacture, intermediate compounds useful in these methods. It also relates to pharmaceutical compositions containing the α-galactoceramide analogs. The methods of manufacture of the invention involve the use of unsaturated intermediate compounds which enable to synthesize α-galactoceramide analogs by a mere metathesis reaction. The α-galactoceramide analogs of the invention are useful as active ingredients of pharmaceutical compositions, particularly in pharmaceutical compositions having anti-cancerous properties.
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