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1.发明申请ALPHA-GALACTOCERAMIDE ANALOGS, THEIR METHODS OF MANUFACTURE, INTERMEDIATE COMPOUNDS USEFUL IN THESE METHODS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 失效ALPHA-GALACTOCERAMIDE ANALOGS，他们的制造方法，这些方法中有用的中间体化合物和含有它们的药物组合物公开(公告)号：US20110028411A1
公开(公告)日：2011-02-03
申请号：US12446431
申请日：2007-10-18
申请人： Didier Dubreuil , Muriel Pipelier , Laurent Micouin , Thomas Lecourt , Vivien Lacone , Marc Bonneville , Jacques Lependu , Anne-Laure Turcot-Dubois
发明人： Didier Dubreuil , Muriel Pipelier , Laurent Micouin , Thomas Lecourt , Vivien Lacone , Marc Bonneville , Jacques Lependu , Anne-Laure Turcot-Dubois
IPC分类号： A61K31/7028 , C07H15/12 , A61P35/00 , A61P37/04
摘要： The invention relates to α-galactoceramide analogs, their methods of manufacture, intermediate compounds useful in these methods. It also relates to pharmaceutical compositions containing the α-galactoceramide analogs. The methods of manufacture of the invention involve the use of unsaturated intermediate compounds which enable to synthesize α-galactoceramide analogs by a mere metathesis reaction. The α-galactoceramide analogs of the invention are useful as active ingredients of pharmaceutical compositions, particularly in pharmaceutical compositions having anti-cancerous properties.
摘要翻译： 本发明涉及α-半乳甘油酰胺类似物，其制备方法，可用于这些方法的中间体化合物。 它还涉及含有α-半乳甘露聚糖类似物的药物组合物。 本发明的制备方法涉及使用不饱和中间体化合物，其能够通过仅仅的复分解反应合成α-半乳甘露聚糖类似物。 本发明的α-半乳糖苷类似物可用作药物组合物的活性成分，特别是在具有抗癌性质的药物组合物中。
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2.发明授权α-galactoceramide analogs, their methods of manufacture, intermediate compounds useful in these methods, and pharmaceutical compositions containing them 失效α-半乳糖苷类似物，其制造方法，可用于这些方法的中间体化合物和含有它们的药物组合物公开(公告)号：US08211859B2
公开(公告)日：2012-07-03
申请号：US12446431
申请日：2007-10-18
申请人： Didier Dubreuil , Muriel Pipelier , Laurent Micouin , Thomas Lecourt , Vivien Lacone , Marc Bonneville , Jacques Lependu , Anne-Laure Turcot-Dubois
发明人： Didier Dubreuil , Muriel Pipelier , Laurent Micouin , Thomas Lecourt , Vivien Lacone , Marc Bonneville , Jacques Lependu , Anne-Laure Turcot-Dubois
摘要： The invention relates to α-galactoceramide analogs, their methods of manufacture, intermediate compounds useful in these methods. It also relates to pharmaceutical compositions containing the α-galactoceramide analogs. The methods of manufacture of the invention involve the use of unsaturated intermediate compounds which enable to synthesize α-galactoceramide analogs by a mere metathesis reaction. The α-galactoceramide analogs of the invention are useful as active ingredients of pharmaceutical compositions, particularly in pharmaceutical compositions having anti-cancerous properties.
摘要翻译： 本发明涉及α-半乳甘油酰胺类似物，其制备方法，可用于这些方法的中间体化合物。 它还涉及含有α-半乳甘露聚糖类似物的药物组合物。 本发明的制备方法涉及使用不饱和中间体化合物，其能够通过仅仅的复分解反应合成α-半乳甘露聚糖类似物。 本发明的α-半乳糖苷类似物可用作药物组合物的活性成分，特别是在具有抗癌性质的药物组合物中。
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