发明授权
US08211885B2 Cyclic indole-3-carboxamides, their preparation and their use as pharmaceuticals
有权
环吲哚-3-甲酰胺，它们的制备及其作为药物的用途
- 专利标题： Cyclic indole-3-carboxamides, their preparation and their use as pharmaceuticals
- 专利标题（中）： 环吲哚-3-甲酰胺，它们的制备及其作为药物的用途
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申请号： US12845317申请日： 2010-07-28
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公开(公告)号： US08211885B2公开(公告)日： 2012-07-03
- 发明人: Henning Steinhagen , Bodo Scheiper , Hans Matter , Hans Ulrich Stilz , Gary McCort
- 申请人： Henning Steinhagen , Bodo Scheiper , Hans Matter , Hans Ulrich Stilz , Gary McCort
- 申请人地址： FR Paris
- 专利权人： Sanofi-Aventis
- 当前专利权人： Sanofi-Aventis
- 当前专利权人地址： FR Paris
- 代理商 Ronald G. Ort
- 优先权： EP08290093 20080131
- 主分类号： A61K31/551
- IPC分类号： A61K31/551 ; A61K31/496 ; C07D209/42 ; C07D401/04 ; C07D401/06 ; C07D405/04 ; C07D409/04
摘要：
The present invention relates to cyclic indole-3-carboxamides of the formula I, wherein A, R, R10, R20, R30, R40, n, p and q have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. Specifically, they inhibit the enzyme renin and modulate the activity of the renin-angiotensin system, and are useful for the treatment of diseases such as hypertension, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.
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