发明授权
- 专利标题： Capped pyrazinoylguanidine sodium channel blockers
- 专利标题（中）： 封闭的吡嗪基胍钠通道阻滞剂
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申请号： US12876615申请日： 2010-09-07
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公开(公告)号： US08211895B2公开(公告)日： 2012-07-03
- 发明人: Michael R. Johnson , Bruce F. Molino , Bruce Sargent , Jianzhong Zhang
- 申请人： Michael R. Johnson , Bruce F. Molino , Bruce Sargent , Jianzhong Zhang
- 申请人地址： US NC Durham
- 专利权人： Parion Sciences, Inc.
- 当前专利权人： Parion Sciences, Inc.
- 当前专利权人地址： US NC Durham
- 代理机构： Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- 主分类号： A61K31/4965
- IPC分类号： A61K31/4965 ; C07D241/02
摘要：
The present application relates to pyrazinoyl guanidine sodium channel blockers having the structure: or a pharmaceutically acceptable salt thereof, where the structural variables are as defined herein. The present invention also relates pharmaceutical compositions comprising the sodium channel blockers and their use in methods of treatment, including the treatment of cardiovascular disease, cystic fibrosis, and chronic bronchitis and in the rehydration of mucosal surfaces and promotion of mucus clearance in a patient.
公开/授权文献
- US20110003832A1 NEW CAPPED Pyrazinoylguanidine SODIUM CHANNEL BLOCKERS 公开/授权日：2011-01-06
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