发明授权
- 专利标题： Combination therapy with IgA1 proteases
- 专利标题（中）： IgA1蛋白酶联合治疗
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申请号： US12177125申请日： 2008-07-21
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公开(公告)号： US08216568B2公开(公告)日： 2012-07-10
- 发明人: Andrew G. Plaut , Jiazhou Qiu
- 申请人： Andrew G. Plaut , Jiazhou Qiu
- 申请人地址： US MA Boston
- 专利权人： Tufts Medical Center
- 当前专利权人： Tufts Medical Center
- 当前专利权人地址： US MA Boston
- 代理机构： Choate Hall & Stewart LLP
- 代理商 Brenda Herschbach Jarrell
- 主分类号： A61K38/48
- IPC分类号： A61K38/48
摘要：
The present invention discloses the use of bacterial IgA1 proteases to treat IgA1 deposition in tissue and organs. Bacterial IgA1 proteases specifically cleave IgA1 molecules and thus provide a means to specifically cleave and remove IgA1 depositions. Accordingly, therapeutic agents for the treatment of diseases characterized by IgA deposition are provided. In particular, therapeutic agents to treat IgA nephropathy, Dermatitis herpetiformis (DH), and Henoch-Schoenlein purpura (HS) are disclosed.
公开/授权文献
- US20090041746A1 Combination therapy with IgA1 proteases 公开/授权日：2009-02-12
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