Invention Grant
US08217060B2 Benzimidazole derivatives useful as TRP M8 receptor modulators
有权
可用作TRP M8受体调节剂的苯并咪唑衍生物
- Patent Title: Benzimidazole derivatives useful as TRP M8 receptor modulators
- Patent Title (中): 可用作TRP M8受体调节剂的苯并咪唑衍生物
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Application No.: US12773083Application Date: 2010-05-04
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Publication No.: US08217060B2Publication Date: 2012-07-10
- Inventor: Raul R. Calvo , Sanath K. Meegalla , Mark R. Player
- Applicant: Raul R. Calvo , Sanath K. Meegalla , Mark R. Player
- Applicant Address: BE Beerse
- Assignee: Janssen Pharmaceutica, NV
- Current Assignee: Janssen Pharmaceutica, NV
- Current Assignee Address: BE Beerse
- Agent Thomas J. Dodd
- Main IPC: A61K31/41
- IPC: A61K31/41 ; A61K31/415
Abstract:
The present invention is directed to benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8 (transient receptor potential M8 channel). More particularly, the compounds of the present invention are useful in the treatment of inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold, anxiety and depression.
Public/Granted literature
- US20100292276A1 BENZIMIDAZOLE DERIVATIVES USEFUL AS TRP M8 RECEPTOR MODULATORS Public/Granted day:2010-11-18
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