发明授权
US08221779B2 Compositions and methods for the delivery of poorly water soluble drugs and methods of treatment
有权
用于递送水溶性差的药物的组合物和方法以及治疗方法
- 专利标题： Compositions and methods for the delivery of poorly water soluble drugs and methods of treatment
- 专利标题（中）： 用于递送水溶性差的药物的组合物和方法以及治疗方法
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申请号： US12394833申请日： 2009-02-27
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公开(公告)号： US08221779B2公开(公告)日： 2012-07-17
- 发明人: Jeffrey M. Jonas , Roger A. Rajewski , Bala Subramaniam , Katherine F. Terranova
- 申请人： Jeffrey M. Jonas , Roger A. Rajewski , Bala Subramaniam , Katherine F. Terranova
- 专利权人： CritiTech, Inc.
- 当前专利权人： CritiTech, Inc.
- 代理机构： Innovar, L.L.C.
- 代理商 Rick Matos
- 主分类号： A61F2/02
- IPC分类号： A61F2/02
摘要：
The present embodiment of the invention is generally directed to compositions comprising suspensions of poorly water-soluble compounds recrystallized in nanoparticulate sizes ranging from 0.1 to 5 μm. In addition, the embodiment of the invention is directed to methods for preparation and administration of these compositions to a patient for prevention and treatment of disease states. In particular, the embodiment of the invention is directed to compositions comprising suspensions of poorly water-soluble compounds, such as antimitotics and antibiotics, in nanoparticulates and methods of prevention and treatment of chronic disease states, such as cancer, by intraperitoneal and intravenous administration of such compositions.