-
1.发明申请COMPOSITIONS AND METHODS FOR THE DELIVERY OF POORLY WATER SOLUBLE DRUGS AND METHODS OF TREATMENT 有权用于输送不合适的水溶性药物的组合物和方法以及治疗方法公开(公告)号：US20090197821A1
公开(公告)日：2009-08-06
申请号：US12394833
申请日：2009-02-27
IPC分类号： A61K31/7048 , A61K31/337 , A61K31/4745 , A61K31/407 , A61K31/704 , A61P35/00
CPC分类号： A61K9/10 , A61K9/0019 , A61K9/14 , A61K9/1688 , A61K47/44
摘要： The present embodiment of the invention is generally directed to compositions comprising suspensions of poorly water-soluble compounds recrystallized in nanoparticulate sizes ranging from 0.1 to 5 μm. In addition, the embodiment of the invention is directed to methods for preparation and administration of these compositions to a patient for prevention and treatment of disease states. In particular, the embodiment of the invention is directed to compositions comprising suspensions of poorly water-soluble compounds, such as antimitotics and antibiotics, in nanoparticulates and methods of prevention and treatment of chronic disease states, such as cancer, by intraperitoneal and intravenous administration of such compositions
摘要翻译： 本发明的本实施方案通常涉及包含以0.1至5μm的纳米颗粒尺寸重结晶的难溶于水的化合物的悬浮液的组合物。 此外，本发明的实施方案涉及用于制备和施用这些组合物给患者以预防和治疗疾病状态的方法。 特别地，本发明的实施方案涉及包含难溶性水溶性化合物如抗虚证和抗生素的悬浮液在纳米颗粒中的组合物，以及通过腹膜内和静脉内施用预防和治疗慢性疾病状态如癌症的方法 这样的组合物
-
2.发明授权Compositions and methods for the delivery of poorly water soluble drugs and methods of treatment 有权用于递送水溶性差的药物的组合物和方法以及治疗方法公开(公告)号：US08221779B2
公开(公告)日：2012-07-17
申请号：US12394833
申请日：2009-02-27
IPC分类号： A61F2/02
CPC分类号： A61K9/10 , A61K9/0019 , A61K9/14 , A61K9/1688 , A61K47/44
摘要： The present embodiment of the invention is generally directed to compositions comprising suspensions of poorly water-soluble compounds recrystallized in nanoparticulate sizes ranging from 0.1 to 5 μm. In addition, the embodiment of the invention is directed to methods for preparation and administration of these compositions to a patient for prevention and treatment of disease states. In particular, the embodiment of the invention is directed to compositions comprising suspensions of poorly water-soluble compounds, such as antimitotics and antibiotics, in nanoparticulates and methods of prevention and treatment of chronic disease states, such as cancer, by intraperitoneal and intravenous administration of such compositions.
摘要翻译： 本发明的本实施方案通常涉及包含以0.1至5μm的纳米颗粒尺寸重结晶的难溶于水的化合物的悬浮液的组合物。 此外，本发明的实施方案涉及用于制备和施用这些组合物给患者以预防和治疗疾病状态的方法。 特别地，本发明的实施方案涉及包含难溶性水溶性化合物如抗虚证和抗生素的悬浮液在纳米颗粒中的组合物，以及通过腹膜内和静脉内施用预防和治疗慢性疾病状态如癌症的方法 这样的组合物。
-
搜索结果
2 条记录 (耗时 0.01 秒)
