A process in which a self-sealing pneumatic tire consisting of a pneumatic tire after vulcanization molding furnished with a sealant layer being uniform without thickness irregularity and a cover sheet layer therefore is produced without the use of an organic solvent and expensive apparatus; and an apparatus therefore. The process is characterized by sequentially performing the operations of injecting a viscous sealant material onto the internal surface of a pneumatic tire (T) after vulcanization molding; diffusing the sealant material into a sheet form by centrifugal force while rotating the pneumatic tire (T) around the tire axis to thereby form a sealant layer (11); injecting a cover material of uncured rubber material or resin material onto the inside surface of the sealant layer (11); diffusing the cover material into a sheet form by centrifugal force while rotating the pneumatic tire (T) around the tire axis to thereby form a cover sheet layer (12); and irradiating the cover sheet layer (12) with electron beams, infrared rays, ultraviolet rays or ultrasonic waves to thereby harden the same.