发明授权
- 专利标题： Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
- 专利标题（中）： 硝化非甾体抗炎化合物，组合物和使用方法
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申请号： US12980077申请日： 2010-12-28
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公开(公告)号： US08222277B2公开(公告)日： 2012-07-17
- 发明人: Richard A. Earl , Maiko Ezawa , Xinqin Fang , David S. Garvey , Ricky D. Gaston , Subhash P. Khanapure , L. Gordon Letts , Chia-En Lin , Ramani R. Ranatunge , Stewart K. Richardson , Joseph D. Schroeder , Cheri A. Stevenson , Shiow-Jyi Wey
- 申请人： Richard A. Earl , Maiko Ezawa , Xinqin Fang , David S. Garvey , Ricky D. Gaston , Subhash P. Khanapure , L. Gordon Letts , Chia-En Lin , Ramani R. Ranatunge , Stewart K. Richardson , Joseph D. Schroeder , Cheri A. Stevenson , Shiow-Jyi Wey
- 申请人地址： FR Sophia Antipolis
- 专利权人： NiCox S.A.
- 当前专利权人： NiCox S.A.
- 当前专利权人地址： FR Sophia Antipolis
- 代理机构： Wilmer Cutler Pickering Hale and Dorr LLP
- 主分类号： A61K31/445
- IPC分类号： A61K31/445 ; A61K31/54 ; A61K31/44 ; A61K31/425 ; A61K31/42 ; A61K31/415 ; A61K31/335 ; A61K31/215 ; A61K31/12
摘要：
The invention also provides methods for treating inflammation, pain and fever; for treating gastrointestinal disorders; for facilitating wound healing; for treating and/or preventing gastrointestinal, renal and/or respiratory toxicities resulting from the use of nonsteroidal antiinflammatory compounds; for treating inflammatory disease states and/or disorders; and for treating and/or preventing ophthalmic diseases and/or disorders comprising administration of novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent.
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