Invention Grant
- Patent Title: Stable formulations of thiadiazole derivative
- Patent Title (中): 稳定的噻二唑衍生物制剂
-
Application No.: US12665740Application Date: 2008-07-07
-
Publication No.: US08222284B2Publication Date: 2012-07-17
- Inventor: Hiroko Kusano , Dinesh Shyamdeo Mishra , Yoshikazu Tashiro , Yosuke Watanabe , Hong Zhuang
- Applicant: Hiroko Kusano , Dinesh Shyamdeo Mishra , Yoshikazu Tashiro , Yosuke Watanabe , Hong Zhuang
- Applicant Address: US IN Indianapolis JP Tokyo
- Assignee: Eli Lilly and Company,Kyowa Hakko Kirin Co., Ltd.
- Current Assignee: Eli Lilly and Company,Kyowa Hakko Kirin Co., Ltd.
- Current Assignee Address: US IN Indianapolis JP Tokyo
- Agent Danica Hostettler
- International Application: PCT/US2008/069301 WO 20080707
- International Announcement: WO2009/009470 WO 20090115
- Main IPC: A61K31/433
- IPC: A61K31/433
Abstract:
The present invention provides formulation parameters and manufacturing conditions for stable pharmaceutical compositions comprising N-{4-(2,2-dimethyl-propionyl)-(5R)-5-[(2-ethylamino-ethanesulfonylamino)-methyl]-5-phenyl-4,5-dihydro-[1,3,4]thiadiazol-2-yl}-2,2-dimethyl-propionamide that minimize undesirable chiral conversion to the less active S enantiomeric form.
Public/Granted literature
- US20110009458A1 STABLE FORMULATIONS OF THIADIAZOLE DERIVATIVE Public/Granted day:2011-01-13
Information query
