利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

17 条记录 (耗时 0.025 秒)

    Infection protectant
    3.
    发明授权
    Infection protectant 失效
    感染保护剂

    公开(公告)号：US5344820A

    公开(公告)日：1994-09-06

    申请号：US879421

    申请日：1992-05-07

    申请人： Shunichi Dosako ,  Hiroko Kusano ,  Eiki Deya ,  Tadashi Idota

    发明人： Shunichi Dosako ,  Hiroko Kusano ,  Eiki Deya ,  Tadashi Idota

    IPC分类号： A61K38/00 ,  C07K14/47 ,  A61K37/16

    CPC分类号： C07K14/4732 ,  A61K38/00 ,  Y10S514/837 ,  Y10S514/867 ,  Y10S514/888 ,  Y10S530/832

    摘要： Disclosed herein is an infection protectant which is excellent in infection protective effects and is also safe. .kappa.-Casein, a sialic-acid-conjugated protein derived from cow milk, and a glycomacropeptide derived from .kappa.-casein, each of which is useful as an active ingredient in this invention, have been found to be effective for the prevention of adhesion of E. coli on cells and also for the inhibition of transformation of lymphocytes by EBV and also to have strong HI activity against virus. The infection protectant of this invention is hence believed to exhibit marked effects for the prevention of occurrence of infectious diarrhea, for mass protection against spreading of influenza, and also against canceration of lymphocytes. Since the active ingredient of the infection protectant is a substance derived from cow milk, it is free of any problem from the viewpoint of safety. Moreover, it is absolutely tasteless and odorless. It can therefore be added to foods for its application.

    摘要翻译： 本文公开了感染保护作用优异且也安全的感染保护剂。 已经发现，kappa-casein是来源于牛奶的唾液酸共轭蛋白质和源自κ-酪蛋白的糖代谢肽，其各自可用作本发明的活性成分， 大肠杆菌在细胞上，也用于通过EBV抑制淋巴细胞的转化，并且还具有针对病毒的强HI活性。 因此，本发明的感染保护剂被认为对于预防感染性腹泻的发生具有显着的效果，用于大规模防止流感扩散以及抗淋巴细胞癌变。 由于感染保护剂的活性成分是来自牛奶的物质，因此从安全性的观点出发，没有任何问题。 此外，它绝对无味无味。 因此可以将其添加到食品中以供应用。

    Compound modified with glycerol derivative
    5.
    发明申请
    Compound modified with glycerol derivative 失效
    用甘油衍生物修饰的化合物

    公开(公告)号：US20060280784A1

    公开(公告)日：2006-12-14

    申请号：US10570623

    申请日：2004-09-03

    申请人： Hisao Nemoto ,  Masahiro Yamauchi ,  Hiroko Kusano ,  Yasuki Kato ,  Motoo Yamasaki ,  Toshiyuki Suzawa

    发明人： Hisao Nemoto ,  Masahiro Yamauchi ,  Hiroko Kusano ,  Yasuki Kato ,  Motoo Yamasaki ,  Toshiyuki Suzawa

    IPC分类号： A61K9/127 ,  A61K31/685 ,  C07F9/02

    CPC分类号： C07D207/452 ,  A61K47/00 ,  A61K47/54 ,  A61K47/6911 ,  B82Y5/00 ,  C07C323/60 ,  C07F9/10 ,  C07K5/0202

    摘要： Objects of the present invention are to provide a compound which is useful as a surface modifier for producing a drug carrier or the like, or a salt thereof; a fine particle comprising the same; and the like. The present invention provides a compound in which a substance to be modified, which is selected from the group consisting of an amphiphilic substance and a hydrophobic substance, is modified with a glycerol derivative represented by the following formula (1): wherein R represents a residue comprising a reactive group for the substance to be modified, which is selected from the group consisting of an amphiphilic substance and a hydrophobic substance or for a spacer capable of binding the substance to be modified, which is selected from the group consisting of an amphiphilic substance and a hydrophobic substance, to R-X, or a group capable of being transformed into the reactive group; n represents an integer of 3 or more; and X represents a residue capable of having the following structure by n in number: directly or via the spacer, or a salt thereof; a fine particle comprising the same; and the like.

    摘要翻译： 本发明的目的是提供一种可用作生产药物载体等的表面改性剂或其盐的化合物; 包含该颗粒的细颗粒; 等等。 本发明提供一种化合物，其中选自由两亲物质和疏水性物质组成的组中的被改性物质用下式（1）表示的甘油衍生物进行改性：其中R表示残基 包括选自两亲物质和疏水性物质的待修饰物质的反应性基团或能够与被修饰物质结合的间隔基，其选自两亲物质 和疏水性物质，至RX或能够转化为反应性基团的基团; n表示3以上的整数， X表示可以直接或经由间隔基或其盐具有n数的以下结构的残基： 包含该颗粒的细颗粒; 等等。

    Method of Producing Fine Particles Surface-Modified with Water-Soluble Substance
    7.
    发明申请
    Method of Producing Fine Particles Surface-Modified with Water-Soluble Substance 有权
    生产用水溶性物质表面改性的微粒的方法

    公开(公告)号：US20080145414A1

    公开(公告)日：2008-06-19

    申请号：US11883169

    申请日：2006-01-27

    申请人： Nobuhiro Yagi ,  Hiroko Sugishita ,  Masashi Nakakura ,  Hiroko Kusano

    发明人： Nobuhiro Yagi ,  Hiroko Sugishita ,  Masashi Nakakura ,  Hiroko Kusano

    IPC分类号： A61K9/127 ,  A61P35/00 ,  A61K47/12

    CPC分类号： A61K9/1271 ,  A61K9/0019 ,  A61K9/107 ,  B01J13/02

    摘要： An object of the present invention is to provide a method of easily producing fine particles comprising a lipid, a fatty acid, or a derivative thereof, surface-modified with a water-soluble substance, etc. There are provided a method of producing a fine particles, surface-modified with a water-soluble substance, which contains the process of dispersing fine particles comprising a lipid, a fatty acid, or a derivative thereof, and dissolving or dispersing a surface modifier which is a lipid derivative, a fatty acid derivative, or an aliphatic hydrocarbon derivative of a water-soluble substance, in a liquid containing a polar organic solvent, and the like.

    摘要翻译： 本发明的目的是提供一种容易地生产包含脂质，脂肪酸或其衍生物的细颗粒的方法，其用水溶性物质表面改性等。提供了一种制备精细的方法 用水溶性物质进行表面改性的粒子，其含有分散包含脂质，脂肪酸或其衍生物的微粒子的工序，溶解或分散作为脂质衍生物的表面改性剂，脂肪酸衍生物 ，或水溶性物质的脂族烃衍生物，在含有极性有机溶剂的液体中等。

    Graphic image processing apparatus
    8.
    发明授权
    Graphic image processing apparatus 失效
    图形图像处理装置

    公开(公告)号：US5796388A

    公开(公告)日：1998-08-18

    申请号：US31036

    申请日：1993-03-11

    申请人： Nae Yasuhara ,  Miyuki Marusawa ,  Hiroshi Yasuhara ,  Hiroko Kusano

    发明人： Nae Yasuhara ,  Miyuki Marusawa ,  Hiroshi Yasuhara ,  Hiroko Kusano

    IPC分类号： A63F13/10 ,  G06F3/02 ,  G06F3/023 ,  G06F3/0484 ,  G06F3/0489 ,  G09B11/10 ,  G09G5/00

    CPC分类号： G06F3/0219 ,  A63F13/10 ,  G06F3/0213 ,  G06F3/04845 ,  G06F3/0489 ,  G09B11/10

    摘要： A graphic image processing apparatus comprises a character pattern selecting device for selecting a predetermined character pattern, a color selecting device for selecting predetermined color data corresponding to the character pattern, a display device for displaying the character pattern, an operating device for moving a cursor on the display device, a first memory for storing data corresponding to the character pattern and color information and reading it out, a second memory for storing display data which are displayed on the display device, a control device for changing the cursor to the character pattern by operating the character pattern selecting device, and an executing device for fixing the character pattern in the second memory so as to display a desired position which is decided by the user by operating the operating device.

    摘要翻译： 图形图像处理装置包括用于选择预定字符图案的字符图形选择装置，用于选择对应于字符图案的预定颜色数据的颜色选择装置，用于显示字符图案的显示装置，用于使光标移动的操作装置 显示装置，用于存储对应于字符图案的数据和颜色信息并读出的第一存储器，用于存储显示在显示装置上的显示数据的第二存储器，用于通过以下步骤将光标改变为字符图案的控制装置： 操作字符图案选择装置，以及用于将字符图案固定在第二存储器中以便通过操作操作装置显示由用户决定的期望位置的执行装置。

    Graphic image generating apparatus with automatic demonstration image generating program
    9.
    发明授权
    Graphic image generating apparatus with automatic demonstration image generating program 失效
    具有自动演示图像生成程序的图形图像生成装置

    公开(公告)号：US5511983A

    公开(公告)日：1996-04-30

    申请号：US66347

    申请日：1993-05-24

    申请人： Masaharu Kashii ,  Nae Yasuhara ,  Hiroko Kusano

    发明人： Masaharu Kashii ,  Nae Yasuhara ,  Hiroko Kusano

    IPC分类号： A63H33/00 ,  A63F13/00 ,  G06T11/80 ,  G09G5/00 ,  G09G5/36 ,  G06F17/00

    CPC分类号： A63F13/218 ,  A63F13/00 ,  A63F13/40 ,  A63F2300/1056

    摘要： An image generating apparatus for preparing a drawing using an image display apparatus. The image generating apparatus has a power source turn-on detection unit for instructing starting of an image forming program for forming a series of consecutive images previously stored in a ROM. When the power turn-on detection unit detects power source turn-on, a power turn-on detection signal is transmitted via an I/O interface to a central processing unit, which then reads a demonstration program from the ROM to start displaying the demonstration image on a display. When the coordinate detection unit and the key switch pressing detecting unit detect the pressure information on buttons on a tablet and key switches, the pressure information is transmitted via the I/O interface to the central processing unit. Under control by the central processing unit, the execution of the image generating program is interrupted and image data formed up to that time is maintained in RAM to enable image data formed by a trajectory drawn on the tablet to be added to the image data maintained in RAM.

    摘要翻译： 一种使用图像显示装置准备图形的图像生成装置。 图像产生装置具有电源开启检测单元，用于指示用于形成预先存储在ROM中的一系列连续图像的图像形成程序的开始。 当电源接通检测单元检测到电源接通时，通过I / O接口将电源接通检测信号发送到中央处理单元，然后中央处理单元从ROM读取演示程序以开始显示演示 图像在显示器上。 当坐标检测单元和按键切换按压检测单元检测到在图形输入板和按键开关上的按钮上的压力信息时，压力信息经由I / O接口传送到中央处理单元。 在中央处理单元的控制下，图像生成程序的执行被中断，并且直到此时形成的图像数据被保持在RAM中，以使得通过在平板电脑上画出的轨迹形成的图像数据被添加到保持在 随机存取存储器。

    METHOD OF INHIBITING LEAKAGE OF DRUG ENCAPSULATED IN LIPOSOMES
    10.
    发明申请
    METHOD OF INHIBITING LEAKAGE OF DRUG ENCAPSULATED IN LIPOSOMES 审中-公开
    抑制在脂质体中浸润的药物的渗漏方法

    公开(公告)号：US20090041835A1

    公开(公告)日：2009-02-12

    申请号：US12139702

    申请日：2008-06-16

    申请人： Yusuki Kato ,  Masahiro Yamauchi ,  Hiroko Kusano ,  Atsushi Ishihara

    发明人： Yusuki Kato ,  Masahiro Yamauchi ,  Hiroko Kusano ,  Atsushi Ishihara

    IPC分类号： A61K9/127 ,  A61K31/407

    CPC分类号： A61K31/55 ,  A61K9/127

    摘要： The present invention provides a method of inhibiting the leakage of a drug encapsulated in liposomes, which comprises satisfying at least two requirements selected from the group consisting of the following three requirements: using at least two lipid bilayers of the liposomes, controlling the average particle size of the liposomes to 120 nm or more, and using lipid having a phase transition temperature higher than in vivo temperature as lipid constituting the liposomes. Also, the present invention provides a liposome preparation which is stable in vivo and satisfies at least two requirements selected from the group consisting of the following three requirements: the number of lipid bilayers of the liposomes is at least two, the liposomes have an average particle size of 120 nm or more, and lipid constituting the liposomes has a phase transition temperature higher than in vivo temperature.

    摘要翻译： 本发明提供一种抑制包封在脂质体中的药物的泄漏的方法，其包括满足选自以下三个要求的至少两个要求：使用脂质体的至少两个脂质双层，控制平均粒径 的脂质体达到120nm以上，并且使用具有比体内温度高的相变温度的脂质作为构成脂质体的脂质。 另外，本发明提供脂质体制剂，其在体内稳定且满足选自以下三个要求的至少两个要求：脂质体的脂质双层数至少为2个，脂质体具有平均粒子 大小为120nm以上，构成脂质体的脂质的相转变温度高于体内温度。